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Canadian Journal of Cardiology

Nocturnal Hemodialysis Restores Impaired Coronary Endothelial Function in End-Stage Renal Patients Receiving Conventional Hemodialysis

      Impaired endothelial function is associated with accelerated atherosclerosis in end-stage renal disease (ESRD) patients. When ESRD patients receiving conventional intermittent hemodialysis (IHD) are converted to nocturnal home hemodialysis (NHD), within 1-2 months the resultant increase in dialysis dose restores both absent brachial artery endothelium-dependent (hyperemia) and markedly impaired endothelium-independent (nitroglycerine; NTG) vasodilatation. We tested the hypothesis that coronary endothelial vasodilator responsiveness to acetylcholine also is enhanced by NHD.
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