Abstract
The presence of left ventricular (LV) dyssynchrony in individuals with metabolic syndrome
(MetS), a predictor of type 2 diabetes (T2D), lacks clarity. We compared LV dyssynchrony
in MetS individuals with and without T2D, and healthy control subjects using speckle-tracking
imaging echocardiography. Ninety-two MetS participants (64 without, 28 with T2D) and
40 control subjects underwent echocardiographic and clinical/biological analyses.
LV-dyssynchrony in the longitudinal axis only was present in all MetS individuals,
but was not further exacerbated by T2D. Strong associations were found with systemic
inflammation, abdominal obesity, and LV mass. Investigations of myocardial dyssynchrony
in the nondiabetic MetS stage might facilitate timely and more effective prevention.
Résumé
La présence de dyssynchronies ventriculaires gauches (VG) chez les individus ayant
un syndrome métabolique (SM), un prédicteur du diabète de type 2 (DT2), est peu documentée.
Nous avons comparé la dyssynchronie VG chez les individus ayant un SM associé ou non
à un DT2, et des sujets témoins en bonne santé au moyen de l’échocardiographie avec
« speckle-tracking ». Quatre-vingt-douze (92) participants ayant un SM (64 non associés au DT2, 28 associés
au DT2) et 40 sujets témoins ont bénéficiés de bilans échocardiographiques, et cliniques/biologiques.
La dyssynchronie VG dans l’axe longitudinal seul était présente chez tous les individus
ayant un SM, mais n’était pas davantage exacerbée par le DT2. Nous avons observé des
liens importants avec l’inflammation systémique, l’obésité abdominale et la masse
VG. Les évaluations de la dyssynchronie myocardique au stade du SM non associé au
diabète pourraient favoriser une prévention prompte et plus efficace.
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Article info
Publication history
Published online: November 08, 2013
Accepted:
October 30,
2013
Received:
August 30,
2013
Footnotes
See editorial by Fitchett and Connelly on pages 270-271 and article by Tadic et al. on pages 325-331 of this issue.
See page 323 for disclosure information.
Identification
Copyright
© 2014 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
