Abstract
Policy positions on salt consumption (based largely on the association of sodium and
blood pressure [BP]) has remained unchanged since the 1970s, until recently. However,
this is beginning to change as new evidence emerges. The evidence supports a strong
association of sodium with BP and cardiovascular disease events in hypertensive individuals,
the elderly, and those who consume > 6 g/d of sodium. However, there is no association
of sodium with clinical events at 3 to 6 g/day and a paradoxical higher rate of events
at < 3 g/day. Therefore, until new evidence emerges, the optimal range of sodium consumption
should be considered to be between 3 and 6 g/d. Population-wide sodium reduction is
not justified in countries such as Canada.
Résumé
Les positions sur les politiques de consommation de sel (basées en grande partie sur
le lien entre le sodium et la pression artérielle [PA]) sont demeurées inchangées
depuis les années 70 jusqu'à tout récemment. Cependant, des changements s’amorcent
étant donné que de nouvelles données scientifiques apparaissent. Les données soutiennent
qu’il existe un lien important entre le sodium et la PA et les événements cardiovasculaires
chez les individus hypertendus, les personnes âgées et les personnes qui consomment
> 6 g/j de sodium. Cependant, on n'observe aucun lien entre le sodium et les événements
cliniques à raison de 3 à 6 g/j, et l'incidence paradoxalement plus élevée d'événements
à < 3 g/j. Par conséquent, jusqu’à ce que de nouvelles données scientifiques voient
le jour, l’étendue optimale de la consommation de sodium devrait être située entre
3 et 6 g/j. La réduction de sodium à l’échelle de la population n’est pas justifiée
dans des pays comme le Canada.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Canadian Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Projected effect of dietary salt reductions on future cardiovascular disease.N Engl J Med. 2010; 362: 590-599
- Mortality benefits from US population-wide reduction in sodium consumption: projections from 3 modeling approaches.Hypertension. 2013; 61: 564-570
- Reducing dietary sodium: the case for caution.JAMA. 2010; 303: 448-449
- The sodium phantom.BMJ. 2011; 343: d6119
- IOM report: evidence fails to support guidelines for dietary salt reduction.JAMA. 2013; 309: 2535-2536
- Effects of chronic excess salt feeding. Induction of self-sustaining hypertension in rats.J Exp Med. 1961; 114: 231
- Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion.Nature. 1962; 194: 480
- Salt in infant foods.Nutr Rev. 1971; 29: 27-30
- Dietary salt and hypertension.Lancet. 1980; 1: 1177-1179
- Blood pressure and nutrient intake in the United States.Science. 1984; 224: 1392-1398
- INTERSALT: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group.BMJ. 1988; 297: 319-328
- Urinary electrolyte excretion, alcohol consumption, and blood pressure in the Scottish heart health study.BMJ. 1988; 297: 329-330
- Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group.BMJ. 1996; 312: 1249-1253
- Inflation in epidemiology: “the proof and measurement of association between two things” revisited.BMJ. 1996; 312: 1659-1661
- Intersalt data. Epidemiological studies should be designed to reduce correction needed for measurement error to a minimum.BMJ. 1997; 315: 485
- Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group.N Engl J Med. 2001; 344: 3-10
- Sodium and potassium intakes among US adults: NHANES 2003-2008.Am J Clin Nutr. 2012; 96: 647-657
- Increased blood pressure during potassium depletion in normotensive men.N Engl J Med. 1989; 320: 1177-1182
- The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels. Results of the Trials of Hypertension Prevention, Phase I.JAMA. 1992; 267: 1213-1220
- Effects of low-sodium diet vs. high-sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride (Cochrane Review).Am J Hypertens. 2012; 25: 1-15
Mente A, O'Donnell MJ, Rangarajan S, et al. PURE-Sodium: Heterogeneity in the associations of urinary sodium and potassium with blood pressure: The PURE sodium study. Paper presented at 2013 ESC Congress. August 31-September 4, 2013; Amsterdam, The Netherlands.
- Validation and comparison of three formulae to estimate sodium and potassium excretion from a single morning fasting urine compared to 24-h measures in 11 countries.J Hypertens. 2014; 32: 1005-1015
- Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials.BMJ. 2013; 346: f1325
- Can dietary sodium intake be modified by public policy?.Clin J Am Soc Nephrol. 2009; 4: 1878-1882
- Trends in 24-hour urinary sodium excretion in the United States, 1957-2003: a systematic review.Am J Clin Nutr. 2010; 92: 1172-1180
- Central regulation of sodium appetite.Exp Physiol. 2008; 93: 177-209
- Cardiorenal end points in a trial of aliskiren for type 2 diabetes.N Engl J Med. 2012; 367: 2204-2213
- Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.N Engl J Med. 2000; 342: 145-153
- Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.N Engl J Med. 2008; 359: 2417-2428
- Major cardiovascular events in hypertensive patients randomized to doxazosin vs. chlorthalidone: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).JAMA. 2000; 283: 1967-1975
- Effects of intensive blood-pressure control in type 2 diabetes mellitus.N Engl J Med. 2010; 362: 1575-1585
- Beta-blockade after myocardial infarction: systematic review and meta-regression analysis.BMJ. 1999; 318: 1730-1737
- 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).Eur Heart J. 2013; 34: 2159-2219
- Physiological aspects of the requirement for sodium in mammals.Nutr Res Rev. 1989; 2: 149-160
- Essential hypertension: renin and aldosterone, heart attack and stroke.N Engl J Med. 1972; 286: 441-449
- Impacts of a national strategy to reduce population salt intake in England: serial cross sectional study.PLoS One. 2012; 7: e29836
- Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.Lancet. 2002; 360: 1903-1913
- Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies.BMJ. 2009; 339: b4567
- Salt intake and cardiovascular disease: why are the data inconsistent?.Eur Heart J. 2013; 34: 1034-1040
- The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes.Diabetes Care. 2011; 34: 861-866
- Dietary salt intake and mortality in patients with type 2 diabetes.Diabetes Care. 2011; 34: 703-709
- Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion.JAMA. 2011; 305: 1777-1785
- Urinary sodium and potassium excretion and risk of cardiovascular events.JAMA. 2011; 306: 2229-2238
- Estimated urinary sodium excretion and risk of heart failure in men and women in the EPIC-Norfolk study.Eur J Heart Fail. 2004; ([Epub ahead of print])
- Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP).BMJ. 2007; 334: 885-888
Article info
Publication history
Published online: February 18, 2014
Accepted:
February 11,
2014
Received:
February 7,
2014
Footnotes
See article by Neal, pages 502-506 of this issue.
See page 511 for disclosure information.
Identification
Copyright
© 2014 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.