Abstract
The fundamental role of inflammation in cardiovascular disease (CVD) has prompted
interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble
urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates
significantly with cardiovascular events and outperforms traditional markers of inflammation
such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore,
of particular interest is the suggestion that suPAR reflects a pathophysiological
pathway more closely linked with subclinical organ damage than CRP. We provide the
first comprehensive review of suPAR in CVD and explore its function and usefulness
in predicting cardiovascular events.
Résumé
Le rôle fondamental de l’inflammation dans la maladie cardiovasculaire (MCV) a suscité
l’intérêt pour de nombreux biomarqueurs qui détectent les degrés subcliniques d’inflammation.
Le récepteur soluble de l’activateur du plasminogène de l’urokinase (suPAR : soluble urokinase plasminogen activator receptor) est un nouveau biomarqueur qui corrèle de façon significative avec les événements
cardiovasculaires et surpasse les marqueurs traditionnels de l’inflammation tels que
la protéine C réactive (CRP : C-reactive protein) dans le pronostic de nombreuses MCV. De plus, la suggestion selon laquelle le suPAR
reflète une voie physiopathologique plus étroitement liée à la lésion subclinique
de l’organe que le CRP revêt un intérêt particulier. Nous présentons la première étude
exhaustive sur le suPAR dans les MCV, et explorons son fonctionnement et son utilité
dans la prédiction des événements cardiovasculaires.
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Article info
Publication history
Published online: March 26, 2015
Accepted:
March 20,
2015
Received:
December 8,
2014
Footnotes
See editorial by Arbel and Strauss, pages 1223-1224 of this issue.
See page 1300 for disclosure information.
Identification
Copyright
© 2015 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
