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Canadian Journal of Cardiology
Case Report| Volume 32, ISSUE 3, P395.e9-395.e10, March 2016

Quintessential Culture-Negative Endocarditis

  • Yoav Keynan
    Correspondence
    Corresponding author: Dr Yoav Keynan, Section of Infectious Diseases and Manitoba HIV Program, Section of Infectious Diseases, Department of Internal Medicine, Medical Microbiology, and Community Health Sciences, Rm 507, 745 Bannatyne Ave, Winnipeg, Manitoba R3E 0J9, Canada. Tel.: +1-204-480-1317; fax: +1204-789-3926.
    Affiliations
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

    Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Lauren MacKenzie
    Affiliations
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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  • Philippe Lagacé-Wiens
    Affiliations
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

    Diagnostic Services of Manitoba, Winnipeg, Manitoba, Canada
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      Abstract

      Bartonella spp are important causes of culture-negative endocarditis, generally causing a subacute insidious form of endocarditis, often leading to a delay in diagnosis. Most patients have fever and often present with signs and symptoms of heart failure. The diagnosis is frequently established only on meticulous examination of the resected heart valve with the polymerase chain reaction technique. We present a case of B quintana mitral and aortic valve endocarditis with associated severe valvular insufficiency and decompensated heart failure precipitated by Streptococcus pneumoniae bacteremia, necessitating urgent surgical valve replacement. Pathologic examination of the valve complemented by serologic and molecular testing established the surprising diagnosis of B quintana endocarditis.

      Résumé

      Les bactéries du genre Bartonella représentent une cause importante de l’endocardite à culture négative, provoquant en général une forme subaiguë insidieuse d’endocardite souvent diagnostiquée tardivement. La plupart des patients touchés souffrent de fièvre et présentent souvent des signes et des symptômes d’insuffisance cardiaque. Le diagnostic n’est en général établi qu’après un examen méticuleux de la valve réséquée en recourant à la méthode d’amplification en chaîne par polymérase. Nous présentons ici un cas d’endocardite des valves mitrale et aortique causée par B. quintana, à laquelle étaient associées une insuffisance valvulaire aiguë et une insuffisance cardiaque décompensée précipitée par une bactériémie à Streptococcus pneumoniae, ce qui a nécessité une intervention chirurgicale d’urgence de remplacement valvulaire. L’examen pathologique de la valve de même que les épreuves sérologiques et analyses moléculaires ont permis d’établir le surprenant diagnostic d’endocardite due à B. quintana.
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      References

        • Dreier J.
        • Vollmer T.
        • Freytag C.C.
        • et al.
        Culture-negative infectious endocarditis caused by Bartonella spp.: 2 case reports and a review of the literature.
        Diagn Microbiol Infect Dis. 2008; 61: 476-483
        • Albrich W.C.
        • Kraft C.
        • Fisk T.
        • Albrecht H.
        A mechanic with a bad valve: blood-culture-negative endocarditis.
        Lancet Infectious Dis. 2004; 4: 777-784
        • Fournier P.E.
        • Lelievre H.
        • Eykyn S.J.
        • et al.
        Epidemiologic and clinical characteristics of Bartonella quintana and Bartonella henselae endocarditis: a study of 48 patients.
        Medicine. 2001; 80: 245-251
        • Fournier P.E.
        • Thuny F.
        • Richet H.
        • et al.
        Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases.
        Clin Infect Dis. 2010; 51: 131-140
        • Foucault C.
        • Brouqui P.
        • Raoult D.
        Bartonella quintana characteristics and clinical management.
        Emerg Infect Dis. 2006; 12: 217-223