Patients on a NOAC with non-permanent AF, a CHADS2 score of 1 or 2, and a previously implanted ICM (Medtronic Reveal XT) were enrolled in a multicenter, single-arm study (REACT.COM
). After a 60-day run-in phase with no AF episodes > 1 hour, NOACs were discontinued and aspirin was prescribed. NOAC was reinitiated in response to any AF episode > 1 hour diagnosed through daily ICM transmissions and continued until the patient was AF-free for > 30 days. Major endpoints included time on NOAC, stroke, and bleeding.