Abstract
Background
The success of behavioural interventions to optimize cardiovascular health is dependent
on adequate cognitive functioning beginning in early life. In this study we aimed
to systematically review studies that examined associations between childhood cognition
and cardiovascular disease (CVD) events in adulthood.
Methods
This study followed the Meta-analysis Of Observational Studies in Epidemiology guidelines
to systematically examine associations between childhood cognition and adult CVD,
coronary heart disease, and stroke hospitalization or mortality events. Literature
was retrieved from EMBASE, MEDLINE, PsycInfo, and CINAHL.
Results
Five longitudinal studies that examined links between childhood cognition and CVD
in adulthood were included. Pooled estimates of unadjusted CVD events indicated a
relative risk of 1.23 (95% confidence interval, 1.12-1.34) per standard deviation
decrease in childhood IQ, whereas the pooled estimate adjusted for biopsychosocial
confounding factors indicated an overall relative risk of 1.16 (95% confidence interval,
1.07-1.26).
Conclusions
Lower childhood IQ is associated with an increased risk of cardiovascular events in
adulthood, even after adjustment for confounding variables. Future research should
examine the behavioural mechanisms by which these risks are mediated to optimize cardiovascular
health.
Résumé
Introduction
Le succès des interventions comportementales sur l’optimisation de la santé cardiovasculaire
dépend d’un fonctionnement cognitif adéquat dès les premières années de la vie. Dans
la présente étude, nous avions pour objectif de réaliser une revue systématique des
études qui ont examiné les associations entre la cognition infantile et les événements
liés à la maladie cardiovasculaire (MCV) à l’âge adulte.
Méthodes
Cette étude a suivi les lignes directrices de la MOOSE (Meta-analysis Of Observational
Studies in Epidemiology, soit la méta-analyse d’études par observation en épidémiologie)
pour examiner systématiquement les associations entre la cognition infantile et la
MCV chez l’adulte, la coronaropathie, et l’hospitalisation à la suite d’un accident
vasculaire cérébrale ou la mortalité. La littérature a été extraite d’EMBASE, de MEDLINE,
de PsycINFO et de CINAHL.
Résultats
Cinq études longitudinales qui ont examiné les liens entre la cognition infantile
et la maladie cardiovasculaire chez les adultes ont été incluses. Les estimations
pondérées des événements non ajustés liés à la MCV ont indiqué un risque relatif de
1,23 (intervalle de confiance à 95 %, 1,12-1,34) par diminution de l’ÉT du QI durant
l’enfance, tandis que l’estimation pondérée ajustée aux facteurs confusionnels biopsychosociaux
a indiqué un risque relatif global de 1,16 (intervalle de confiance à 95 %, 1,07-1,26).
Conclusions
Un QI plus faible durant l’enfance est associé à une augmentation du risque d’événements
cardiovasculaires à l’âge adulte, même après l’ajustement des variables confusionnelles.
Les recherches futures devraient examiner les mécanismes comportementaux par lesquels
ces risques sont influencés pour optimiser la santé cardiovasculaire.
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Article info
Publication history
Published online: August 29, 2016
Accepted:
August 4,
2016
Received:
June 6,
2016
Footnotes
See page 241 for disclosure information.
Identification
Copyright
© 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
