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Canadian Journal of Cardiology

FLUOROQUINOLONE INDUCES HUMAN AORTIC FIBROBLAST-MEDIATED EXTRACELLULAR MATRIX DYSREGULATION

      Use of fluoroquinolone (FQ) antibiotics is common and widespread in the community. FQ are highly associated with connective tissue weakening causing severe tendon ruptures. Clinical studies have also shown increased aortic events after FQ exposure. It is possible that a similar mechanism of connective tissue weakening may exacerbate aortopathy leading to aortic rupture/dissection after exposure to FQ. Aortic fibroblasts mediate extracellular matrix (ECM) homeostasis and prevent aortic rupture by synthesizing collagen matrix and expressing endogenous protease inhibitors (TIMP). We hypothesized that FQ induces ECM dysregulation by downregulating collagen and TIMP expression thereby increasing the capacity for matrix metalloproteinase (MMP)-mediated ECM disruption.
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