Abstract
Background
We studied the independent and joint associations of leisure-time physical activity
(LTPA) and cardiorespiratory fitness (CRF) with the risk of sudden cardiac death (SCD)
among middle-aged men.
Methods
The participants were 2656 randomly selected men aged 42-60 years at baseline who
were followed for 19 years. LTPA was assessed using a questionnaire modified from
the Minnesota LTPA Questionnaire and CRF using a respiratory gas exchange analyzer
during maximal exercise test. The participants were divided into 4 groups according
to the level of LTPA and CRF dichotomized at the lowest tertiles.
Results
Men with low CRF had a 1.6 (95% confidence interval [CI], 1.1-2.3; P = 0.011) times higher risk of SCD than men with high CRF after adjustment for conventional
risk factors. Men with low LTPA had a 1.4 (95% CI, 1.0-2.0; P = 0.032) times higher SCD risk than men with high LTPA after these adjustments. Men
with low CRF and low LTPA had a 2.2 (95% CI, 1.4-3.3) times higher SCD risk than men
with high CRF and high LTPA adjusting for conventional risk factors (P = 0.044 for interaction).
Conclusions
It seems that low LTPA increases the risk of SCD particularly among men with low CRF
but the level of LTPA does not modify the incidence of SCD among men with high CRF.
Résumé
Contexte
Nous avons étudié les associations indépendantes et conjointes entre l’activité physique
durant les loisirs (APL) et la capacité cardiorespiratoire (CCR) d’une part et, d’autre
part, le risque de mort subite d’origine cardiaque (MSC) chez des hommes d’âge moyen.
Méthodologie
Les participants étaient 2656 hommes choisis au hasard, qui étaient âgés de 42 à 60
ans au début de l’étude et ont été suivis pendant 19 ans. L’APL a été évaluée à l’aide
d’une version modifiée du Minnesota LTPA Questionnaire, et la CCR a été mesurée par
un analyseur des échanges gazeux respiratoires lors d’un test d’effort maximal. Les
participants ont été divisés en quatre groupes en fonction des valeurs d’APL et de
CCR scindées en deux catégories aux tertiles inférieurs.
Résultats
Les hommes ayant une CCR peu élevée présentaient un risque de MSC 1,6 fois (intervalle
de confiance [IC] à 95 %, 1,1-2,3; p = 0,011) plus grand que ceux ayant une CCR élevée, après ajustement pour tenir compte
des facteurs de risque habituels. Les hommes ayant une APL peu élevée présentaient
un risque de MSC 1,4 fois (IC à 95 %, 1,0-2,0; p = 0,032) plus grand que ceux ayant une APL élevée, après ajustement pour tenir compte
de ces facteurs. Les hommes présentant des valeurs de CCR faible et une APL faible
avaient un risque de MSC 2,2 fois (IC à 95 %, 1,4-3,3) plus élevé que ceux présentant
des valeurs élevées de CCR et d’APL après ajustement pour tenir compte des facteurs
de risque habituels (p = 0,044 pour l’interaction).
Conclusions
Il semble qu’une APL peu élevée augmente le risque de MSC, en particulier chez les
hommes dont la CCR est faible, mais le niveau d’APL ne modifie pas l’incidence de
la MSC chez ceux dont la CCR est élevée.
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Article info
Publication history
Published online: December 11, 2017
Accepted:
December 5,
2017
Received:
September 26,
2017
Footnotes
See page 293 for disclosure information.
Identification
Copyright
© 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
