Abstract
Cryoglobulinemic vasculitis is a rare and frequently fatal type of myocarditis. Cardiac
manifestations in type 1 cryoglobulinemic vasculitis have never been reported to our
knowledge. We report a rare case of type 1 cryoglobulinemic vasculitis with cardiac
involvement in a patient who experienced progressive heart failure during the diagnosis.
The diagnosis was made by the presence of cryoglobulins and endomyocardial biopsy
results. After bortezomib-containing treatments, plasma cryoglobulin levels returned
to normal, and the patient's clinical condition gradually improved.
Résumé
La vascularite cryoglobulinémique est une forme de myocardite rare, mais souvent fatale.
À notre connaissance, les manifestations cardiaques de la vascularite cryoglobulinémique
de type 1 n’ont jamais été rapportées. Nous faisons état d’un cas rare de vascularite
cryoglobulinémique de type 1 associant une atteinte cardiaque chez un patient qui
souffrait d’insuffisance cardiaque progressive lors du diagnostic. Le diagnostic a
été posé en raison de la présence de cryoglobulines et des résultats de la biopsie
endomyocardique. Après les traitements à base de bortézomib, les concentrations plasmatiques
en cryoglobuline revenaient à la normale, et l’état clinique du patient s’est graduellement
amélioré.
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References
- Biologic and clinical significance of cryoglobulins. A report of 86 cases.Am J Med. 1974; 57: 775-788
- Characteristics and outcome of 49 patients with symptomatic cryoglobulinaemia.Rheumatology (Oxford). 2002; 41: 290-300
- Cryoglobulin-induced cardiomyopathy.J Am Coll Cardiol. 2010; 55: e13
- Heart involvement in essential mixed cryoglobulinemia.Ric Clin Lab. 1986; 16: 381-383
Article info
Publication history
Published online: December 27, 2017
Accepted:
December 16,
2017
Received:
November 26,
2017
Footnotes
See page 343.e3 for disclosure information.
Identification
Copyright
© 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
