Canadian Journal of Cardiology

Recent Developments in Sex-Related Differences in Presentation, Prognosis, and Management of Coronary Artery Disease

  • Author Footnotes
    ∗ These authors contributed equally to this work.
    Mahraz Parvand
    ∗ These authors contributed equally to this work.
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
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  • Author Footnotes
    ∗ These authors contributed equally to this work.
    Erin Rayner-Hartley
    ∗ These authors contributed equally to this work.
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
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  • Tara Sedlak
    Corresponding author: Dr Tara Sedlak, Division of Cardiology, Vancouver General Hospital, DHHC, 2775 Laurel St, Level 9, Vancouver, British Columbia V5Z 1M9, Canada. Tel.: +1-604-875-5487.
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    Search for articles by this author
  • Author Footnotes
    ∗ These authors contributed equally to this work.
Published:January 15, 2018DOI:


      Coronary artery disease (CAD) is the most prevalent type of heart disease among women and men. Sex-related differences in the presentation, prognosis, and management of patients with CAD has been increasingly studied. Compared with men, women are more likely to present with multiple comorbidities, have a higher prevalence of psychological risk factors, and present with atypical symptoms. These factors, along with delays in seeking medical attention, might contribute to sex-related treatment differences in women with stable angina and acute coronary syndrome. This review article highlights recent evidence examining sex-related differences in stable CAD patients with obstructive CAD, nonobstructive CAD, as well as myocardial infarction.


      La coronaropathie est le type de cardiopathie le plus courant chez les femmes et les hommes. De plus en plus d’études abordent les différences liées au sexe qui touchent le tableau clinique, le pronostic et la prise en charge de la coronaropathie. Comparativement aux hommes, les femmes sont plus susceptibles de présenter des maladies concomitantes multiples, une prévalence plus élevée des facteurs de risque psychologiques et des symptômes atypiques. Ces facteurs, conjugués avec le retard à demander des soins médicaux, pourraient contribuer à des différences de traitement liées au sexe chez les femmes présentant une angine stable et un syndrome coronarien aigu. Cet article de synthèse expose des données probantes récentes sur les différences liées au sexe dans les cas stables de coronaropathie obstructive, non obstructive ou concomitante à un infarctus du myocarde.
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