Abstract
Résumé
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Canadian Journal of CardiologyReferences
- Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies.Lancet HIV. 2017; 4: e349-e356
- Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals.AIDS. 2010; 24: 1527-1535
- Association between HIV infection, antiretroviral therapy, and risk of acute myocardial infarction: a cohort and nested case-control study using Quebec’s public health insurance database.J Acquir Immune Defic Syndr. 2011; 57: 245-253
- HIV infection and the risk of acute myocardial infarction.JAMA Intern Med. 2013; 173: 614-622
- Cardiovascular disease and HIV infection.Curr HIV/AIDS Rep. 2013; 10: 199-206
- Multimorbidity in older adults with cardiovascular disease.J Am Coll Cardiol. 2018; 71: 2149-2161
- Polypharmacy and comorbidity in heart failure.BMJ. 2003; 327: 513-514
- Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents.(Available at:)http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdfDate accessed: May 26, 2018
- Interactions of human organic anion transporters with diuretics.J Pharmacol Exp Ther. 2004; 308: 1021-1029
- Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity.Antivir Ther. 2014; 19: 687-692
Vemlidy (tenofovir alafenamide) [product monograph]. Mississauga, Ontario, Canada, Gilead Sciences Canada.
Lasix (furosemide) [product monograph]. Laval, Quebec, Canada, Sanofi-Aventis Canada.
Zaroxolyn (metolazone) [product monograph]. Laval, Quebec, Canada, Sanofi-Aventis Canada.
Burinex (bumetanide) [product monograph]. Thornhill, Ontario, Canada, LEO Pharma.
Chlorthalidone [product monograph]. Vaughan, Ontario, Canada, AA Pharma Canada.
- Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats.J Pharm Pharm Sci. 2012; 15: 208-220
Aldactone (spironolactone) [product monograph]. Kirkland, Quebec, Canada, Pfizer Canada.
Inspira (eplerenone) [product monograph]. Kirkland, Quebec, Canada, Pfizer Canada.
Terazosin (NTP-Terazosin) [product monograph]. Toronto, Ontario, Canada, Teva Canada Limited.
Prazosin (Teva-Prazosin) [product monograph]. Toronto, Ontario, Canada, Teva Canada Limited.
Cardura (doxazosin) [product monograph]. Kirkland, Quebec, Canada, Pfizer Canada Inc.
Hytrin (terazocin) [prescribing information]. North Chicago, Ill, Abbott Laboratories.
- Effects of alpha-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport.PLoS One. 2012; 7e30697
Captopril [product monograph]. Weston, Ontario, Canada, APOTEX.
Enalapril [product monograph]. Boucherville, Quebec, Canada, Sandoz Canada.
Zestril (lisinopril) [product monograph]. Mississauga, Ontario, Canada, AstraZeneca Canada.
Perindopril [product monograph]. Weston, Ontario, Canada, APOTEX.
Ramipril [product monograph]. Boucherville, Quebec, Canada, Sandoz Canada.
Lotensin (Benazepril) [product monograph]. Dorval, Quebec, Canada, Novartis Pharmaceuticals Canada Inc.
Mavik (trandolapril) [product monograph]. Etobicoke, Ontario, Canada, BGP Pharma ULC.
Accupril (quinapril) [product monograph]. Kirkland, Quebec, Canada, Pfizer Canada Inc.
Monopril (fosinopril) [product monograph]. Montreal, Quebec, Canada, Bristol-Myers Squibb Canada Inc.
Inhibace (cilazapril) [product monograph]. Mississauga, Ontario, Canada, H-LR Limited.
Cozaar (losartan) [product monograph]. Kirkland, Quebec, Canada, Merck Canada.
Avapro (irbesartan) [product monograph]. Laval, Quebec, Canada, Sanofi-Aventis Canada.
Norvir (ritonavir) Prescribing Information. Saint-Laurent, Quebec, Canada, AbbVie Corporation.
Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) [product monograph]. Mississauga, Ontario, Canada, Gilead Sciences Canada Inc.
Sustiva (efavirenz) [prescribing information]. Montreal, Quebec, Canada, Bristol-Myers Squibb Canada.
Intelence (etravirine) [product monograph]. Toronto, Ontario, Canada, Janssen Inc.
Diovan (valsartan) [product monograph]. Dorval, Quebec, Canada, Novartis Pharmaceuticals Canada.
Micardis (telmisartan) [product monograph]. Burlington, Ontario, Canada, Boehringer Ingelheim Canada.
Teveten (eprosartan) [product monograph]. Etobicoke, Ontario, Canada, BGP Pharma.
Atacand (candesartan) [product monograph]. Mississauga, Ontario, Canada, AstraZeneca Canada.
Lopresor (metoprolol) [product monograph]. Dorval, Quebec, Canada, Novartis Pharmaceuticals Canada.
Carvedilol [product monograph]. WoodBridge, Ontario, Canada, Auro Pharma.
Bisoprolol [product monograph]. Boucherville, Quebec, Canada, Sandoz Canada.
Tenormin (atenolol) [product monograph]. Mississauga, Ontario, Canada, AstraZeneca Canada.
Trandate (labetalol hydrochloride tablets) [product monograph]. Saint-Laurent, Quebec, Canada, Paladin.
Nadolol [product monograph]. Vaughan, Ontario, Canada, AA Pharma.
Sotalol [product monograph]. Etobicoke, Ontario, Canada, Mylan.
German P, Mathias A, Wei L, et al. The effect of cobicistat on cytochrome P450 2D6, 2B6 and P-glycoprotein using phenotypic probes (abstract O_01). 12th International Workshop on Clinical Pharmacology of HIV Therapy. Miami, FL, April 13-15, 2011.
- Effect of low-dose ritonavir (100 mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers.Clin Pharmacol Ther. 2005; 78: 664-674
- Extreme bradycardia due to multiple drug-drug interactions in a patient with HIV post-exposure prophylaxis containing lopinavir-ritonavir.Br J Clin Pharmacol. 2011; 71: 621-623
- Pharmacokinetic interactions between the hormonal emergency contraception, levonorgestrel (Plan B), and efavirenz.Infect Dis Obstet Gynecol. 2012; 2012: 137192
Hydralazine [product monograph]. Vaughan, Ontario, Canada, AA Pharma.
- Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels.FEBS Lett. 1999; 452: 165-169
Transderm Nitro (nitroglycerin) [product monograph]. Dorval, Québec, Canada, Novartis Pharmaceuticals Canada Inc.
Entresto (sacubitril/valsartan) [product monograph]. Dorval, Quebec, Canada, Novartis Pharmaceuticals Canada.
Prezcobix (darunavir/cobicistat) [product monograph]. Toronto, Ontario, Canada, Janssen Inc.
Evotaz (atazanavir/cobicistat) [product monograph]. Montreal, Quebec, Canada, Bristol-Myers Squibb Canada.
Kaletra (lopinavir/ritonavir) [prescribing information]. Saint Laurent, Quebec, Canada, AbbVie Corporation.
Cholestyramine-Odan (Cholestyramine) [product monograph]. Pointe-Claire, Quebec, Canada, Odan Laboratories Ltd.
- Management of dyslipidemia in HIV-infected patients.Clin Lipidol. 2011; 6: 447-462
Ezetimibe [product monograph]. Boucherville, Quebec, Canada, Sandoz Canada.
Bezafibrate [product monograph]. Boucherville, Quebec, Canada, Jamp Pharma.
Fenofibrate [product monograph]. Boucherville, Quebec, Canada, Sandoz Canada.
- Lack of an effect of ritonavir alone and lopinavir-ritonavir on the pharmacokinetics of fenofibric acid in healthy volunteers.Pharmacotherapy. 2016; 36: 49-56
Gemfibrozil [product monograph]. Toronto, Ontario, Canada, Teva Canada.
- Gemfibrozil concentrations are significantly decreased in the presence of lopinavir-ritonavir.J Acquir Immune Defic Syndr. 2009; 52: 235-239
Zocor (simvastatin) [product monograph]. Kirkland, Quebec, Canada, Merck Canada.
Lovastatin [product monograph]. Brampton, Ontario, Canada, Sanis Health.
- Pharmacokinetic interactions between protease inhibitors and statins in HIV-seronegative volunteers: ACTG Study A5047.AIDS. 2002; 16: 569-577
- Rhabdomyolysis and severe hepatotoxicity due to a drug-drug interaction between ritonavir and simvastatin. Could we use the most cost-effective statin in all human immunodeficiency virus-infected patients?.Enferm Infecc Microbiol Clin. 2014; 32 ([in Spanish]): 579-582
- Safety and efficacy of HMG-CoA reductase inhibitors for treatment of hyperlipidemia in patients with HIV infection.Pharmacotherapy. 2000; 20: 1066-1071
Lipitor (atorvastatin) [product monograph]. Kirkland, Quebec, Canada, TM Pfizer Ireland.
Custodio J, West S, SenGupta D, et al. Evaluation of the drug-drug interaction potential between cobicistat-boosted protease inhibitors and statins [abstract O_04]. 18th International Workshop on Clinical Pharmacology of Antiviral Therapy. Chicago, IL June 14-16, 2017.
Prezista (darunavir) [product monograph]. Toronto, Ontario, Canada, Janssen Inc.
Crestor (rosuvastatin) [product monograph]. Mississauga, Ontario, Canada, AstraZeneca Canada.
Reyataz (atazanavir) [product monograph]. Montreal, Quebec, Canada, Bristol-Myers Squibb Canada.
- Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin.J Cardiovasc Pharmacol. 2008; 51: 605-610
- Steady-state pharmacokinetic interactions of darunavir/ritonavir with lipid-lowering agent rosuvastatin.J Clin Pharmacol. 2012; 52: 922-931
Ramanathan S, Wang H, Stondell T, Cheng A, Kearney BP. Pharmacokinetics and drug interaction profile of cobicistat boosted-elvitegravir with atazanavir, rosuvastatin or rifabutin (abstract O_03) 13th International Workshop on Clinical Pharmacology of HIV Therapy. Barcelona, Spain April 16-18, 2012.
Viramune and Viramune XR (nevirapine) [product monograph]. Burlington, Ontario, Canada, Boehringer Ingelheim (Canada) Ltd.
Edurant (rilpivirine) [product monograph]. Toronto, Ontario, Canada, Janssen Inc.
Sekar V, Spinosa-Guzman S, Marien K, et al. Pharmacokinetic drug-drug interaction between Prezista and pravastatin (abstract 54). 8th International Workshop on Clinical Pharmacology of HIV Therapy. Budapest, Hungary, April 16-18, 2007.
Carr RA, Andre AK, Bertz RJ, et al. Concomitant administration of ABT-378/ritonavir results in a clinically important pharmacokinetic interaction with atorvastatin but not pravastatin (abstract 1644). 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario, Canada, September 17-20, 2000.
- Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study.J Acquir Immune Defic Syndr. 2005; 39: 307-312
Lescol (fluvastatin) [product monograph]. Dorval, Quebec, Canada, Novartis Pharmaceuticals Canada.
- Lack of pharmacokinetic interactions between pitavastatin and efavirenz or darunavir/ritonavir.J Acquir Immune Defic Syndr. 2014; 67: 390-396
- PCSK9 inhibitors: a new era of lipid lowering therapy.World J Cardiol. 2017; 9: 76-91
- Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate.Clin Pharmacokinet. 2008; 47: 285-295
- Differential influence of the antiretroviral pharmacokinetic enhancers ritonavir and cobicistat on intestinal P-glycoprotein transport and the pharmacokinetic/pharmacodynamic disposition of dabigatran.Antimicrob Agents Chemother. 2017; 61: e01201-e01217
- Successful co-administration of dabigatran etexilate and protease inhibitors ritonavir/lopinavir in a patient with atrial fibrillation.Thromb Haemost. 2014; 112: 836-838
- Novel oral anticoagulants and HIV: dabigatran use with antiretrovirals.BMJ Case Rep. 2015; 2015 (bcr2015211651)
Rivaroxaban (Xarelto) [product monograph]. Toronto, Ontario, Canada, Bayer Inc.
Eliquis (apixaban) [product monograph]. Kirkland, Quebec, Canada, Pfizer Canada Inc.
- Gastrointestinal bleeding associated with rivaroxaban administration in a treated patient infected with human immunodeficiency virus.Swiss Med Wkly. 2014; 144: w13906
- Postoperative bleeding after administration of a single dose of rivaroxaban to a patient receiving antiretroviral therapy.Drug Saf. 2015; 2: 11
- Venous thromboembolism due to suspected interaction between rivaroxaban and nevirapine.Can J Hosp Pharm. 2013; 66: 125-129
Lixiana (Edoxaban) [product monograph]. Laval, Quebec, Canada, Servier Canada Inc.
Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) [package insert]. Foster City, CA, Gilead Sciences.
Tybost (cobicistat) [package insert]. Foster City, CA, Gilead Sciences.
- Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.Clin Pharmacokinet. 2005; 44: 1227-1246
- Warfarin-antiretroviral interactions.Ann Pharmacother. 2009; 43: 322-328
- An unexpected interaction between warfarin and cobicistat-boosted elvitegravir.AIDS. 2015; 29: 985-986
Prasugrel (Effient) [product monograph]. Toronto, Ontario, Canada, Eli Lilly Canada Inc.
- Effect of intrinsic and extrinsic factors on the clinical pharmacokinetics and pharmacodynamics of prasugrel.Clin Pharmacokinet. 2010; 49: 777-798
- Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.Clin Pharmacol Ther. 2007; 81: 735-741
Plavix (clopidogrel) [product monograph]. Laval, Quebec, Canada, Sanofi Aventis Canada.
- In vitro analysis and quantitative prediction of efavirenz inhibition of eight cytochrome P450 (CYP) enzymes: major effects on CYPs 2B6, 2C8, 2C9 and 2C19.Drug Metab Pharmacokinet. 2013; 28: 362-371
- Pharmacokinetic interactions between etravirine and non-antiretroviral drugs.Clin Pharmacokinet. 2011; 50: 25-39
- Ticagrelor: the first novel reversible P2Y(12) inhibitor.Expert Opin Pharmacother. 2013; 14: 237-245
Brilinta (ticagrelor) [product monograph]. Mississauga, Ontario, Canada, Astra Zeneca Canada Inc.
Cordarone (amiodarone) [product monograph]. Kirkland, Quebec, Canada, T.M. Sanofi-Synthelabo.
- Antiretroviral therapy increases serum concentrations of amiodarone.Ann Pharmacother. 1999; 33: 645-646
Multaq (dronedarone) [product monograph]. Laval, Quebec, Canada, Sanofi-Aventis Canada.
Tambocor (flecainide) [product monograph]. Thornleigh, New South Wales, Australia, Nova Pharmaceuticals.
- Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide.Eur J Clin Pharmacol. 2015; 71: 549-567
- Clinical pharmacokinetics of mexiletine.Clin Pharmacokinet. 1999; 37: 361-384
Rythmol (propafenone) [product monograph]. Etobicoke, Ontario, Canada, BG Pharma.
Norvasc (amlodipine) [product monograph]. Kirkland, Quebec, Canada, Pfizer Canada.
Diltiazem [product monograph]. Boucherville, Quebec, Canada, Sandoz Canada.
Renedil (felodipine) [product monograph]. Laval, Quebec, Canada, Sanofi-Aventis Canada.
Adalat XL (nifedipine extended-release) [product monograph]. Mississauga, Ontario, Canada, Bayer.
Isoptin SR (verapamil sustained-release) [product monograph]. Saint-Laurent, Quebec, Canada, BGP Pharma ULC.
- Pharmacokinetic interactions between indinavir plus ritonavir and calcium channel blockers.Clin Pharmacol Ther. 2005; 78: 143-153
- Nifedipine-lopinavir/ritonavir severe interaction: a case report.AIDS. 2007; 21: 119-120
- Clinical Drug Interaction Studies – Study Design, Data Analysis, and Clinical Implications Guidance for Industry.(Available at:)https://www.fda.gov/downloads/drugs/guidances/ucm292362.pdfDate accessed: June 5, 2018
- Digoxin toxicity and ritonavir: a drug interaction mediated through p-glycoprotein?.AIDS. 2003; 17: 1577-1578
- Life-threatening digoxin toxicity due to drug-drug interactions in an HIV-positive man.Int J STD AIDS. 2017; 28: 297-301
Lancora (ivabradine) [product monograph]. Laval, Quebec, Canada, Servier Canada.
- Symptomatic bradycardia and heart failure triggered by ivabradine in a patient receiving antiretroviral therapy.Rev Esp Cardiol (Engl Ed). 2016; 69: 529-530
- Long QTc and torsades de pointes in human immunodeficiency virus disease.Pacing Clin Electrophysiol. 1997; 20: 2810-2816
- QTc interval prolongation in patients with HIV and AIDS.J Natl Med Assoc. 2005; 97: 1657-1661
- Prolongation of the QTc interval in HIV-infected individuals compared to the general population.Infection. 2017; 45: 659-667
- QTc interval prolongation in HIV-infected patients: a case-control study by 24-hour Holter ECG recording.BMC Cardiovasc Disord. 2012; 12: 124
- Prevalence and risk factors of prolonged QTc interval in HIV-infected patients: results of the HIV-HEART study.HIV Clin Trials. 2009; 10: 261-268
- Prevalence and predictors of long corrected QT interval in HIV-positive patients: a multicenter study.J Cardiovasc Med (Hagerstown). 2017; 18: 539-544
- Autonomic neuropathy and prolongation of QT interval in human immunodeficiency virus infection.Clin Auton Res. 1995; 5: 48-52
- Viral load and CD4+ cell count as risk factors for prolonged QT interval in HIV-infected subjects: a cohort-nested case-control study in an outpatient population.Cardiology. 2010; 117: 105-111
- Risk of QTc prolongation in a cohort of opioid-dependent HIV-infected patients on methadone maintenance therapy.Clin Infect Dis. 2013; 57: 1189-1194
- Characterization and natural course of cardiac autonomic nervous dysfunction in HIV-infected patients.AIDS. 1997; 11: 751-757
- Thorough QT/QTc study of ritonavir-boosted saquinavir following multiple-dose administration of therapeutic and supratherapeutic doses in healthy participants.J Clin Pharmacol. 2012; 52: 520-529
- Blockade of HERG channels by HIV protease inhibitors.Lancet. 2005; 365: 682-686
- Boosted protease inhibitors and the electrocardiographic measures of QT and PR durations.AIDS. 2011; 25: 367-377
- Drug-induced QT interval prolongation: mechanisms and clinical management.Ther Adv Drug Saf. 2012; 3: 241-253
- QTc interval screening in methadone treatment.Ann Intern Med. 2009; 150: 387-395
- Evaluation of HIV drug interaction Web sites.Ann Pharmacother. 2003; 37: 1577-1586
Article info
Publication history
Footnotes
See page 336 for disclosure information.