Canadian Journal of Cardiology
Editorial| Volume 35, ISSUE 10, P1281-1282, October 2019

When the Myocardium Gets MIFfed: Macrophage Inhibitory Factor as a Biomarker in Acute Coronary Artery Disease

      Survival after acute myocardial infarction has improved significantly in the past years and decades. Besides the developments in interventional treatment options, the increasing public awareness of typical symptoms has contributed to a reduced time lag between the onset of symptoms and intervention. However, the differential diagnosis of acute or chronic myocardial ischemia in patients who present with atypical symptoms can be much less straightforward.
      • Andruchow J.E.
      • Kavsak P.A.
      • McRae A.D.
      Contemporary emergency department management of patients with chest pain: a concise review and guide for the high-sensitivity troponin era.
      Despite current guidelines that allow for 1-hour ruling in or out of non–ST-elevation myocardial infarction for certain high-sensitivity troponin assays, patients are often left anxious and stressed during the waiting period for the second troponin measurement. For other disorders like coronary microvascular disease, diagnostic plasma or serum markers have not yet been identified.
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