For almost 20 years, cell therapy has been touted as a natural solution to replace heart muscle lost at the time of myocardial infarction.
- Nadal-Ginard B.
- Kajstura J.
- Leri A.
- Anversa P.
Myocyte death, growth, and regeneration in cardiac hypertrophy and failure.
Circ Res. 2003; 92: 139-150
- Urbanek K.
- Quaini F.
- Tasca G.
- et al.
Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy.
Proc Natl Acad Sci USA. 2003; 100: 10440-10445
3But recent scandals
- Orlic D.
- Kajstura J.
- Chimenti S.
- et al.
Bone marrow cells regenerate infarcted myocardium.
Nature. 2001; 410: 701-705
4and failed clinical trials
- Davis D.R.
Cardiac stem cells in the post-Anversa era.
Eur Heart J. 2019; 40: 1039-1041
5have done little to inspire confidence in a jaded medical community. Although a portion of the blame lies in the early hype and hyperbole raising unrealistic expectations, some of the initial mechanisms that assumed how transplanted cells would modify heart function have proved to be spectacularly wrong and prompted many to consider new directions to restore injured tissue.
- Jeyaraman M.M.
- Rabbani R.
- Copstein L.
- et al.
Autologous bone marrow stem cell therapy in patients with ST-elevation myocardial infarction: a systematic review and meta-analysis.
Can J Cardiol. 2017; 33: 1611-1623
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- Myocyte death, growth, and regeneration in cardiac hypertrophy and failure.Circ Res. 2003; 92: 139-150
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Published online: July 10, 2019
Accepted: July 7, 2019
Received: July 3, 2019
See article by Marvasti et al., pages 1311–1321 of this issue.
See page 1279 for disclosure information.
© 2019 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
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- CD34+ Stem Cells: Promising Roles in Cardiac Repair and RegenerationCanadian Journal of CardiologyVol. 35Issue 10
- PreviewCell therapy has received significant attention as a novel therapeutic approach to restore cardiac function after injury. CD34-positive (CD34+) stem cells have been investigated for their ability to promote angiogenesis and contribute to the prevention of remodelling after infarct. However, there are significant differences between murine and human CD34+ cells; understanding these differences might benefit the therapeutic use of these cells. Herein we discuss the function of the CD34 cell and highlight the similarities and differences between murine and human CD34 cell function, which might explain some of the differences between the animal and human evolutions.