Canadian Journal of Cardiology

Do These Genes Make My Heart Look Fat? Why Molecular Changes Matter in Congenital Heart Disease

      In recent years, molecular testing in the medical world has exploded in popularity, mainly due to advances in the diagnosis and treatment of cancer and the pursuit of individualized medicine. Meanwhile, non-neoplastic fields seem to have lagged behind when it comes to harnessing the power of the genome at the bedside. This may be because the molecular landscape of non-neoplastic disease is often highly complex, with increased influence of environmental factors and frequent involvement of multiple genes. However, the importance of genetic changes in these fields is becoming more and more evident, leading to new insights into disease pathogenesis, improved prognostication, and promising new therapies.
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