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Canadian Journal of Cardiology

One Ring to Rule Them All: Continuous Monitoring of Patients With Secondary Atrial Fibrillation Points to a Unifying Underlying Mechanism

  • Martin Aguilar
    Affiliations
    Department of Medicine and Research Centre, Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada
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  • Jordi Heijman
    Affiliations
    Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands

    Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany
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  • Dobromir Dobrev
    Affiliations
    Department of Medicine and Research Centre, Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada

    Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany

    Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas, USA
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  • Stanley Nattel
    Correspondence
    Corresponding author: Dr Stanley Nattel, Department of Medicine and Research Centr, Montreal Heart Institute and University of Montréal 5000 Belanger St, Montréal, Québec H1T 1C8, Canada.
    Affiliations
    Department of Medicine and Research Centre, Montréal Heart Institute and University of Montréal, Montréal, Québec, Canada

    Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany

    L‘Institut Hospitalo-Universitaire L‘Institut de Rythmologie et Modélisation Cardiaque (IHU LIRYC) and Fondation Bordeaux Université Bordeaux, Bordeaux, France
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Published:January 22, 2021DOI:https://doi.org/10.1016/j.cjca.2021.01.018
      In Tolkien’s monumental trilogy, following the gifting of the rings of power, a verse was written among the Free Peoples that contained the above phrase about a uniting power that ruled all the other rings---Could there be a uniting principle that brings together many of the diverse forms of atrial fibrillation (AF) thought to be pathophysiologically unrelated?
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      References

        • Andrade J.
        • Khairy P.
        • Dobrev D.
        • Nattel S.
        The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms.
        Circ Res. 2014; 114: 1453-1468
        • Andrade J.G.
        • Aguilar M.
        • Atzema C.
        • et al.
        The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society comprehensive guidelines for the management of atrial fibrillation.
        Can J Cardiol. 2020; 36: 1847-1948
        • Lubitz S.A.
        • Yin X.
        • Rienstra M.
        • et al.
        Long-term outcomes of secondary atrial fibrillation in the community: the Framingham Heart Study.
        Circulation. 2015; 131: 1648-1655
        • Gillinov A.M.
        • Bagiella E.
        • Moskowitz A.J.
        • et al.
        Rate control versus rhythm control for atrial fibrillation after cardiac surgery.
        N Engl J Med. 2016; 374: 1911-1921
        • Arsenault K.A.
        • Yusuf A.M.
        • Crystal E.
        • et al.
        Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery.
        Cochrane Database Syst Rev. 2013; 1: CD003611
        • Megens M.R.
        • Churilov L.
        • Thijs V.
        New-onset atrial fibrillation after coronary artery bypass graft and long-term risk of stroke: a meta-analysis.
        J Am Heart Assoc. 2017; 6e007558
        • Kosmidou I.
        • Chen S.
        • Kappetein A.P.
        • et al.
        New-onset atrial fibrillation after PCI or CABG for left main disease: the EXCEL Trial.
        J Am Coll Cardiol. 2018; 71: 739-748
        • Butt J.H.
        • Olesen J.B.
        • Gundlund A.
        • et al.
        Long-term thromboembolic risk in patients with postoperative atrial fibrillation after left-sided heart valve surgery.
        JAMA Cardiol. 2019; 4: 1139-1147
        • Lin M.H.
        • Kamel H.
        • Singer D.E.
        • Wu Y.L.
        • Lee M.
        • Ovbiagele B.
        Perioperative/postoperative atrial fibrillation and risk of subsequent stroke and/or mortality.
        Stroke. 2019; 50: 1364-1371
        • Aguilar M.
        • Nattel S.
        Postoperative atrial fibrillation after noncardiac surgery: maybe not so benign after all.
        Can J Cardiol. 2019; 35: 1423-1425
        • McIntyre W.F.
        • Wang J.
        • Benz A.P.
        • et al.
        Device-detected atrial fibrillation before and after hospitalisation for noncardiac surgery or medical illness: insights from ASSERT.
        Can J Cardiol. 2021; 37: 803-809
        • McIntyre W.F.
        • Connolly S.J.
        • Healey J.S.
        Atrial fibrillation occurring transiently with stress.
        Curr Opin Cardiol. 2018; 33: 58-65
        • Cardoso R.
        • Nasir K.
        Primary prevention of cardiovascular disease: 2019 and beyond.
        Nat Rev Cardiol. 2019; 16: 387-388
        • Yao C.
        • Veleva T.
        • Scott L.
        • et al.
        Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation.
        Circulation. 2018; 138: 2227-2242
        • Dobrev D.
        • Aguilar M.
        • Heijman J.
        • Guichard J.B.
        • Nattel S.
        Postoperative atrial fibrillation: mechanisms, manifestations and management.
        Nat Rev Cardiol. 2019; 16: 417-436
        • Heijman J.
        • Muna A.P.
        • Veleva T.
        • et al.
        Atrial myocyte NLRP3/CaMKII nexus forms a substrate for postoperative atrial fibrillation.
        Circ Res. 2020; 127: 1036-1055
        • Fauchier L.
        • Clementy N.
        • Bisson A.
        • et al.
        Prognosis in patients with atrial fibrillation and a presumed "temporary cause" in a community-based cohort study.
        Clin Res Cardiol. 2017; 106: 202-210
        • Asanin M.R.
        • Vasiljevic Z.M.
        • Matic M.D.
        • et al.
        The long-term risk of stroke in patients with acute myocardial infarction complicated with new-onset atrial fibrillation.
        Clin Cardiol. 2009; 32: 467-470
        • Zusman O.
        • Amit G.
        • Gilutz H.
        • Zahger D.
        The significance of new onset atrial fibrillation complicating acute myocardial infarction.
        Clin Res Cardiol. 2012; 101: 17-22
        • Quon M.J.
        • Behlouli H.
        • Pilote L.
        Anticoagulant use and risk of ischemic stroke and bleeding in patients with secondary atrial fibrillation associated with acute coronary syndromes, acute pulmonary disease, or sepsis.
        JACC Clin Electrophysiol. 2018; 4: 386-393

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