Abstract
Transthyretin (TTR) cardiac amyloidosis is a systemic disease caused by amyloid deposits
in several systemic organs. The thickening of the yellow ligament because of amyloid
deposits results in spinal canal stenosis. This study reports a case of mutant-type
TTR cardiac amyloidosis in a patient with recurrent spinal canal stenosis. To our
knowledge, this is the first study to report pathologic amyloid involvement in both
spinal and cardiac tissues of a patient with hereditary TTR amyloidosis. It is important
to be aware of underlying amyloidosis as a cause of spinal canal stenosis, especially
regarding refractory diseases in older adults.
Résumé
L'amyloïdose cardiaque à transthyrétine (TTR) est une maladie systémique causée par
des dépôts amyloïdes dans plusieurs organes systémiques. L'épaississement du ligament
jaune en raison des dépôts amyloïdes entraîne une sténose du canal rachidien. Cette
étude rapporte un cas d'amyloïdose cardiaque liée à un mutant du gène TTR chez un
patient présentant une sténose récurrente du canal rachidien. À notre connaissance,
il s'agit de la première étude à signaler une implication amyloïde pathologique dans
les tissus rachidiens et cardiaques d'un patient atteint d'amyloïdose à TTR héréditaire.
Il est important d'être conscient de l'amyloïdose sous-jacente en tant que cause de
sténose du canal rachidien, notamment en ce qui concerne les maladies réfractaires
chez les personnes âgées.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Canadian Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Heart failure resulting from age-related cardiac amyloid disease associated with wild-type transthyretin: a prospective, observational cohort study.Circulation. 2016; 133: 282-290
- Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis.Mod Pathol. 2015; 28: 201-207
- Carpal tunnel syndrome and spinal canal stenosis: harbingers of transthyretin amyloid cardiomyopathy?.Clin Res Cardiol. 2019; 108: 1324-1330
- Tenosynovial and cardiac amyloidosis in patients undergoing carpal tunnel release.J Am Coll Cardiol. 2018; 72: 2040-2050
Article info
Publication history
Published online: February 12, 2021
Accepted:
February 8,
2021
Received:
December 6,
2020
Footnotes
See page 1291 for disclosure information.
Identification
Copyright
© 2021 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
