Advertisement
Canadian Journal of Cardiology
Review| Volume 37, ISSUE 11, P1828-1836, November 2021

Extreme Heat and Cardiovascular Health: What a Cardiovascular Health Professional Should Know

Published:November 17, 2021DOI:https://doi.org/10.1016/j.cjca.2021.08.008

      Abstract

      As global temperatures continue to rise, extreme heat events are becoming more frequent and intense. Extreme heat affects cardiovascular health as it is associated with a greater risk of adverse cardiovascular events, especially for adults with preexisting cardiovascular diseases. Nonetheless, the pathophysiology underlying the association between extreme heat and cardiovascular risk remains understudied. Furthermore, specific recommendations to mitigate the effects of extreme heat on cardiovascular health remain limited to guide clinical practice within the context of a warming climate. The overall objective of this review article is to raise awareness that extreme heat poses a risk for cardiovascular health. Specifically, the review discusses why cardiovascular healthcare professionals should care about extreme heat, how extreme heat affects cardiovascular health, and recommendations to minimise the cardiovascular consequences of extreme heat. Future research directions are also provided to further our understating of the cardiovascular health consequences of extreme heat. A better awareness and understanding of the cardiovascular consequences of extreme heat will help cardiovascular health professionals assess the risk and optimise the care of their patients exposed to an increasingly warm climate.

      Résumé

      Avec la hausse continue des températures à l'échelle mondiale, les épisodes de chaleur extrême deviennent plus fréquents et plus intenses. Cette chaleur extrême affecte la santé cardiovasculaire car elle est associée à un risque accru d'événements cardiovasculaires indésirables, en particulier chez les adultes souffrant de maladies cardiovasculaires préexistantes. Néanmoins, la pathophysiologie qui sous-tend l'association entre chaleur extrême et risque cardiovasculaire reste peu étudiée. En outre, les recommandations spécifiques visant à atténuer les effets de la chaleur extrême sur la santé cardiovasculaire restent limitées afin de guider la pratique clinique dans le contexte du réchauffement climatique. L'objectif général de cette revue de littérature est de sensibiliser les professionnels de la santé cardiovasculaire aux risques que posent la chaleur extrême pour la santé cardiovasculaire. Plus précisément, nous aborderons les raisons pour lesquelles les professionnels de la santé cardiovasculaire devraient se préoccuper de la chaleur extrême, la manière dont la chaleur extrême affecte la santé cardiovasculaire et les recommandations visant à minimiser les conséquences cardiovasculaires de la chaleur extrême. Des orientations de recherche futures sont également proposées afin de mieux appréhender les conséquences de la chaleur extrême sur la santé cardiovasculaire. Une meilleure connaissance et compréhension des conséquences cardiovasculaires de la chaleur extrême aidera les professionnels de la santé cardiovasculaire à évaluer le risque et à optimiser les soins de leurs patients exposés à un climat de plus en plus chaud.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Canadian Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Watts N.
        • Amann M.
        • Arnell N.
        • et al.
        The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come.
        Lancet. 2018; 392: 2479-2514
        • Patz J.A.
        • Frumkin H.
        • Holloway T.
        • Vimont D.J.
        • Haines A.
        Climate change: challenges and opportunities for global health.
        JAMA. 2014; 312: 1565-1580
        • Bobb J.F.
        • Obermeyer Z.
        • Wang Y.
        • Dominici F.
        Cause-specific risk of hospital admission related to extreme heat in older adults.
        JAMA. 2014; 312: 2659-2667
        • Gasparrini A.
        • Guo Y.
        • Hashizume M.
        • et al.
        Mortality risk attributable to high and low ambient temperature: a multicountry observational study.
        Lancet. 2015; 386: 369-375
        • Bouchama A.
        • Dehbi M.
        • Mohamed G.
        • et al.
        Prognostic factors in heat wave related deaths: a meta-analysis.
        Arch Intern Med. 2007; 167: 2170-2176
        • Kenney W.L.
        • Craighead D.H.
        • Alexander L.M.
        Heat waves, aging, and human cardiovascular health.
        Med Sci Sports Exerc. 2014; 46: 1891-1899
        • Stewart S.
        • Keates A.K.
        • Redfern A.
        • McMurray J.J.
        Seasonal variations in cardiovascular disease.
        Nat Rev Cardiol. 2017; 14: 654
        • Claeys M.J.
        • Rajagopalan S.
        • Nawrot T.S.
        • Brook R.D.
        Climate and environmental triggers of acute myocardial infarction.
        Eur Heart J. 2016; 38: 955-960
        • Liu C.
        • Yavar Z.
        • Sun Q.
        Cardiovascular response to thermoregulatory challenges.
        Am J Physiol Heart Circ Physiol. 2015; 309: H1793-H1812
        • Robine J.M.
        • Cheung S.L.
        • Le Roy S.
        • et al.
        Death toll exceeded 70,000 in Europe during the summer of 2003.
        C R Biol. 2008; 331: 171-178
        • Barriopedro D.
        • Fischer E.M.
        • Luterbacher J.
        • Trigo R.M.
        • Garcia-Herrera R.
        The hot summer of 2010: redrawing the temperature record map of Europe.
        Science. 2011; 332: 220-224
        • Gasparrini A.
        • Guo Y.
        • Sera F.
        • et al.
        Projections of temperature-related excess mortality under climate change scenarios.
        Lancet Planet Health. 2017; 1: e360-e367
        • Alahmad B.
        • Khraishah H.
        • Shakarchi A.F.
        • et al.
        Cardiovascular mortality and exposure to heat in an inherently hot region: implications for climate change.
        Circulation. 2020; 141: 1271-1273
        • Bai L.
        • Li Q.
        • Wang J.
        • et al.
        Increased coronary heart disease and stroke hospitalisations from ambient temperatures in Ontario.
        Heart. 2018; 104: 673-679
        • Semenza J.C.
        • Rubin C.H.
        • Falter K.H.
        • et al.
        Heat-related deaths during the July 1995 heat wave in Chicago.
        N Engl J Med. 1996; 335: 84-90
        • Semenza J.C.
        • McCullough J.E.
        • Flanders W.D.
        • McGeehin M.A.
        • Lumpkin J.R.
        Excess hospital admissions during the July 1995 heat wave in Chicago.
        Am J Prev Med. 1999; 16: 269-277
        • Naughton M.P.
        • Henderson A.
        • Mirabelli M.C.
        • et al.
        Heat-related mortality during a 1999 heat wave in Chicago.
        Am J Prev Med. 2002; 22: 221-227
        • Empana J.-P.
        • Sauval P.
        • Ducimetiere P.
        • Tafflet M.
        • Carli P.
        • Jouven X.
        Increase in out-of-hospital cardiac arrest attended by the medical mobile intensive care units, but not myocardial infarction, during the 2003 heat wave in Paris, France.
        Crit Care Med. 2009; 37: 3079-3084
        • Argaud L.
        • Ferry T.
        • Le Q.H.
        • et al.
        Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon, France.
        Arch Intern Med. 2007; 167: 2177-2183
        • Bunker A.
        • Wildenhain J.
        • Vandenbergh A.
        • et al.
        Effects of air temperature on climate-sensitive mortality and morbidity outcomes in the elderly; a systematic review and meta-analysis of epidemiological evidence.
        EBioMedicine. 2016; 6: 258-268
        • Cheng J.
        • Xu Z.
        • Bambrick H.
        • et al.
        Cardiorespiratory effects of heatwaves: a systematic review and meta-analysis of global epidemiological evidence.
        Environ Res. 2019; 177: 108610
        • Weilnhammer V.
        • Schmid J.
        • Mittermeier I.
        • et al.
        Extreme weather events in europe and their health consequences—a systematic review.
        Int J Hyg Environ Health. 2021; 233: 113688
        • Chen K.
        • Breitner S.
        • Wolf K.
        • et al.
        Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany 1987-2014.
        Eur Heart J. 2019; 40: 1600-1608
        • Gostimirovic M.
        • Novakovic R.
        • Rajkovic J.
        • et al.
        The influence of climate change on human cardiovascular function.
        Arch Environ Occup Health. 2020; 75: 406-414
        • Minson C.T.
        • Wladkowski S.L.
        • Cardell A.F.
        • Pawelczyk J.A.
        • Kenney W.L.
        Age alters the cardiovascular response to direct passive heating.
        J Appl Physiol. 1998; 84: 1323-1332
        • Gagnon D.
        • Romero S.A.
        • Ngo H.
        • et al.
        Healthy aging does not compromise the augmentation of cardiac function during heat stress.
        J Appl Physiol. 2016; 121: 885-892
        • Crandall C.G.
        • Wilson T.E.
        • Marving J.
        • et al.
        Effects of passive heating on central blood volume and ventricular dimensions in humans.
        J Physiol. 2008; 586: 293-301
        • Wilson T.E.
        • Brothers R.M.
        • Tollund C.
        • et al.
        Effect of thermal stress on Frank-Starling relations in humans.
        J Physiol. 2009; 587: 3383-3392
        • Bundgaard-Nielsen M.
        • Wilson T.E.
        • Seifert T.
        • Secher N.H.
        • Crandall C.G.
        Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans.
        J Physiol. 2010; 588: 3333-3339
        • Ravanelli N.M.
        • Hodder S.G.
        • Havenith G.
        • Jay O.
        Heart rate and body temperature responses to extreme heat and humidity with and without electric fans.
        JAMA. 2015; 313: 724-725
        • Kenny G.P.
        • Poirier M.P.
        • Metsios G.S.
        • et al.
        Hyperthermia and cardiovascular strain during an extreme heat exposure in young versus older adults.
        Temperature. 2017; 4: 79-88
        • Gagnon D.
        • Romero S.A.
        • Cramer M.N.
        • et al.
        Age modulates physiological responses during fan use under extreme heat and humidity.
        Med Sci Sports Exerc. 2017; 49: 2333-2342
        • Morris N.B.
        • English T.
        • Hospers L.
        • Capon A.
        • Jay O.
        The effects of electric fan use under differing resting heat index conditions: a clinical trial.
        Ann Intern Med. 2019; 171: 675-677
        • Greaney J.L.
        • Stanhewicz A.E.
        • Proctor D.N.
        • Alexander L.M.
        • Kenney W.L.
        Impairments in central cardiovascular function contribute to attenuated reflex vasodilation in aged skin.
        J Appl Physiol. 2015; 119: 1411-1420
        • Gravel H.
        • Chaseling G.K.
        • Barry H.
        • Debray A.
        • Gagnon D.
        Cardiovascular control during heat stress in older adults: time for an update.
        Am J Physiol Heart Circ Physiol. 2021; 320: H411-H416
        • Gagnon D.
        • Romero S.A.
        • Cramer M.N.
        • Jay O.
        • Crandall C.G.
        Cardiac and Thermal strain of elderly adults exposed to extreme heat and humidity with and without electric fan use.
        JAMA. 2016; 316: 989-991
        • Cui J.
        • Arbab-Zadeh A.
        • Prasad A.
        • Durand S.
        • Levine B.D.
        • Crandall C.G.
        Effects of heat stress on thermoregulatory responses in congestive heart failure patients.
        Circulation. 2005; 112: 2286-2292
        • Cui J.
        • Boehmer J.P.
        • Blaha C.
        • et al.
        Chronic heart failure does not attenuate the total activity of sympathetic outflow to skin during whole-body heating.
        Circ Heart Fail. 2013; 6: 271-278
        • Green D.J.
        • Maiorana A.J.
        • Siong J.H.
        • et al.
        Impaired skin blood flow response to environmental heating in chronic heart failure.
        Eur Heart J. 2006; 27: 338-343
        • Andersen I.
        • Jensen P.L.
        • Junker P.
        • Thomsen A.
        • Wyon D.P.
        The effects of moderate heat stress on patients with ischemic heart disease.
        Scand J Work Environ Health. 1976; 2: 256-268
        • Sheldahl L.M.
        • Wilke N.A.
        • Dougherty S.
        • Tristani F.E.
        Cardiac response to combined moderate heat and exercise in men with coronary artery disease.
        Am J Cardiol. 1992; 70: 186-191
        • Walsh J.
        • Prpic R.
        • Goodman C.
        • Dawson B.
        • Hung J.
        Thermoregulatory responses in post–coronary artery bypass surgery and healthy males during moderate exercise in warm and cool environments.
        J Cardiopulm Rehabil. 2002; 22: 31-37
        • Braunwald E.
        Control of myocardial oxygen consumption: physiologic and clinical considerations.
        Am J Cardiol. 1971; 27: 416-432
        • Duncker D.J.
        • Koller A.
        • Merkus D.
        • Canty Jr., J.M.
        Regulation of coronary blood flow in health and ischemic heart disease.
        Prog Cardiovasc Dis. 2015; 57: 409-422
        • Duncker D.J.
        • Bache R.J.
        Regulation of coronary blood flow during exercise.
        Physiol Rev. 2008; 88: 1009-1086
        • Goodwill A.G.
        • Dick G.M.
        • Kiel A.M.
        • Tune J.D.
        Regulation of coronary blood flow.
        Compr Physiol. 2017; 7: 321-382
        • Kaski J.C.
        • Crea F.
        • Gersh B.J.
        • Camici P.G.
        Reappraisal of ischemic heart disease.
        Circulation. 2018; 138: 1463-1480
        • Shah S.J.
        • Lam C.S.
        • Svedlund S.
        • et al.
        Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF.
        Eur Heart J. 2018; 39: 3439-3450
        • Luqman N.
        • Sung R.J.
        • Wang C.-L.
        • Kuo C.-T.
        Myocardial ischemia and ventricular fibrillation: pathophysiology and clinical implications.
        Int J Cardiol. 2007; 119: 283-290
        • Giannetti N.
        • Juneau M.
        • Arsenault A.
        • et al.
        Sauna-induced myocardial ischemia in patients with coronary artery disease.
        Am J Med. 1999; 107: 228-233
        • Keatinge W.R.
        • Coleshaw S.R.
        • Easton J.C.
        • et al.
        Increased platelet and red cell counts, blood viscosity, and plasma cholesterol levels during heat stress, and mortality from coronary and cerebral thrombosis.
        Am J Med. 1986; 81: 795-800
        • Epstein Y.
        • Yanovich R.
        Heatstroke.
        N Engl J Med. 2019; 380: 2449-2459
        • Leon L.R.
        • Helwig B.G.
        Heat stroke: role of the systemic inflammatory response.
        J Appl Physiol. 2010; 109: 1980-1988
        • Meyer M.A.
        • Ostrowski S.R.
        • Overgaard A.
        • et al.
        Hypercoagulability in response to elevated body temperature and central hypovolemia.
        J Surg Res. 2013; 185: e93-e100
        • Faulkner S.H.
        • Jackson S.
        • Fatania G.
        • Leicht C.A.
        The effect of passive heating on heat shock protein 70 and interleukin-6: a possible treatment tool for metabolic diseases?.
        Temperature. 2017; 4: 292-304
        • Hoekstra S.P.
        • Bishop N.C.
        • Faulkner S.H.
        • Bailey S.J.
        • Leicht C.A.
        Acute and chronic effects of hot water immersion on inflammation and metabolism in sedentary, overweight adults.
        J Appl Physiol. 2018; 125: 2008-2018
        • Laing S.J.
        • Jackson A.R.
        • Walters R.
        • et al.
        Human blood neutrophil responses to prolonged exercise with and without a thermal clamp.
        J Appl Physiol. 2008; 104: 20-26
        • Boldt L.H.
        • Fraszl W.
        • Röcker L.
        • et al.
        Changes in the haemostatic system after thermoneutral and hyperthermic water immersion.
        Eur J Appl Physiol. 2008; 102: 547-554
        • Borgman M.A.
        • Zaar M.
        • Aden J.K.
        • et al.
        Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans.
        Am J Physiol Regul Integr Comp Physiol. 2019; 316: R145-R156
        • Bhaskaran K.
        • Armstrong B.
        • Hajat S.
        • et al.
        Heat and risk of myocardial infarction: hourly level case-crossover analysis of MINAP database.
        BMJ. 2012; 345e8050
        • Libby P.
        • Pasterkamp G.
        • Crea F.
        • Jang I.K.
        Reassessing the mechanisms of acute coronary syndromes.
        Circ Res. 2019; 124: 150-160
        • Libby P.
        • Tabas I.
        • Fredman G.
        • Fisher E.A.
        Inflammation and its resolution as determinants of acute coronary syndromes.
        Circ Res. 2014; 114: 1867-1879
        • Ontario Ministry of Health; Ministry of Long-Term Care
        A harmonized heat warning and information system for Ontario (HWIS).
        (Available at:) (Accessed August 7, 2021)
        • Kosatsky T.
        • King N.
        • Henry B.
        How Toronto and Montréal (Canada) respond to heat.
        in: Kirch W. Bertollini R. Menne B. Extreme Weather Events and Public Health Responses. Springer, 2005: 167-171
        • Loughnan M.E.
        • Nicholls N.
        • Tapper N.J.
        The effects of summer temperature, age and socioeconomic circumstance on acute myocardial infarction admissions in Melbourne, Australia.
        Int J Health Geogr. 2010; 9: 41
        • Morris N.B.
        • Chaseling G.K.
        • English T.
        • et al.
        Electric fans for cooling during hot weather: biophysical modelling with global weather analysis.
        Lancet Planet Health. 2021; 5: E368-E377
        • Centers for Disease Control and Prevention
        Extreme Heat Prevention Guide (Part 2 of 3).
        2021 (Available at:)
        • Graham C.
        • Morris N.B.
        • Harwood A.E.
        • Jay O.
        Ad libitum water consumption off-sets the thermal and cardiovascular strain exacerbated by dehydration during a 3-h simulated heatwave.
        Eur J Appl Physiol. 2020; 120: 391-399
        • Morris N.B.
        • Gruss F.
        • Lempert S.
        • et al.
        A preliminary study of the effect of dousing and foot immersion on cardiovascular and thermal responses to extreme heat.
        JAMA. 2019; 322: 1411-1413
        • Cramer M.N.
        • Huang M.
        • Moralez G.
        • Crandall C.G.
        Keeping older individuals cool in hot and moderately humid conditions: wetted clothing with and without an electric fan.
        J Appl Physiol. 2020; 128: 604-611
        • Okazaki K.
        • Kamijo Y.
        • Takeno Y.
        • et al.
        Effects of exercise training on thermoregulatory responses and blood volume in older men.
        J Appl Physiol. 2002; 93: 1630-1637
        • Pelliccia A.
        • Sharma S.
        • Gati S.
        • et al.
        2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease: the Task Force on Sports Cardiology and Exercise in Patients With Cardiovascular Disease of the European Society of Cardiology (ESC).
        Eur Heart J. 2021; 42: 17-96
        • Shaposhnikov D.
        • Revich B.
        • Bellander T.
        • et al.
        Mortality related to air pollution with the moscow heat wave and wildfire of 2010.
        Epidemiology. 2014; 25: 359-364
        • Scortichini M.
        • de Sario M.
        • de’Donato F.K.
        • et al.
        Short-term effects of heat on mortality and effect modification by air pollution in 25 Italian cities.
        Int J Environ Res Public Health. 2018; 15: 1771
        • Mack G.W.
        • Shannon L.M.
        • Nadel E.R.
        Influence of beta-adrenergic blockade on the control of sweating in humans.
        J Appl Physiol. 1986; 61: 1701-1705
        • Pescatello L.S.
        • Mack G.W.
        • Leach C.N.
        • Nadel E.R.
        Effect of beta-adrenergic blockade on thermoregulation during exercise.
        J Appl Physiol. 1987; 62: 1448-1452
        • Gordon N.F.
        • Kruger P.E.
        • van Rensburg J.P.
        • et al.
        Effect of beta-adrenoceptor blockade on thermoregulation during prolonged exercise.
        J Appl Physiol. 1985; 58: 899-906
        • Holowatz L.A.
        • Jennings J.D.
        • Lang J.A.
        • Kenney W.L.
        Systemic low-dose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans.
        J Appl Physiol. 2010; 108: 1575-1581
        • Layton J.B.
        • Li W.
        • Yuan J.
        • et al.
        Heatwaves, medications, and heat-related hospitalization in older Medicare beneficiaries with chronic conditions.
        PLoS One. 2020; 15e0243665
        • Nam Y.H.
        • Bilker W.B.
        • Leonard C.E.
        • et al.
        Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study.
        Sci Rep. 2019; 9: 4685
        • Minson C.T.
        • Kenney W.L.
        Age and cardiac output during cycle exercise in thermoneutral and warm environments.
        Med Sci Sports Exerc. 1997; 29: 75-81
        • Rowell L.B.
        Human cardiovascular adjustments to exercise and thermal stress.
        Physiol Rev. 1974; 54: 75-159