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Canadian Journal of Cardiology

A Gut Feeling: Lipopolysaccharide Links Gut Dysbiosis With Inflammatory Atrial Cardiomyopathy, Obesity, and Atrial Fibrillation

  • Anke C. Fender
    Affiliations
    Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany
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  • Dobromir Dobrev
    Correspondence
    Corresponding author: Dr Dobromir Dobrev, Hufelandstr. 55, 45147-Essen, Germany. Tel.: +49201-723-85551; fax: +49201-723-5593.
    Affiliations
    Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany

    Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, Texas, USA

    Department of Medicine and Research Center, Montréal Heart Institute and Université de Montréal, Montréal, Québec, Canada
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Published:September 29, 2022DOI:https://doi.org/10.1016/j.cjca.2022.09.025
      Atrial fibrillation (AF) is the most common form of cardiac arrhythmia. Onset and progression of AF are promoted by diverse triggers acting upon a vulnerable atrial substrate created by anatomic, electrical, and structural changes, often resulting from an atrial cardiomyopathy.
      • Goette A.
      • Kalman J.M.
      • Aguinaga L.
      • et al.
      EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterisation, and clinical implication.
      Inflammatory signalling is an emerging unifying principle in AF pathophysiology,
      • Dobrev D.
      • Heijman J.
      • Hiram R.
      • Li N.
      • Nattel S.
      Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology.
      ,
      • Aguilar M.
      • Heijman J.
      • Dobrev D.
      • Nattel S.
      One ring to rule them all: continuous monitoring of patients with secondary atrial fibrillation points to a unifying underlying mechanism.
      but the driving risk factors and comorbidities leading to AF-promoting atrial inflammation remain poorly defined.
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