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Canadian Journal of Cardiology

Revascularization in Spontaneous Coronary Artery Dissection: Do Clinical Outcomes Vary Based on Initial Presentation?

Published:October 19, 2022DOI:https://doi.org/10.1016/j.cjca.2022.10.015
      Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic, nontraumatic cause of myocardial infarction (MI) and potential sudden cardiac death, most commonly presenting in younger (< 50 years of age) women.
      • Saw J.
      • Humphries K.
      • Aymong E.
      • et al.
      Spontaneous coronary artery dissection: clinical outcomes and risk of recurrence.
      Coronary artery obstruction is caused by the spontaneous formation of an intramural hematoma, which leads to occlusion of the true lumen resulting in infarction rather than plaque rupture.
      • Hayes S.
      • Tweet M.
      • Adlam D.
      Spontaneous coronary artery dissection.
      The estimated prevalence is at least 4% of all acute coronary syndromes (ACS), which is likely an underestimate owing to challenges in establishing the diagnosis for myriad reasons, including unfamiliarity on part of health care providers and lack of recognition of the possibility of acute coronary syndromes in this younger, mostly female, and otherwise healthy patient population.
      • Saw J.
      • Starovoytov A.
      • Humphries K.
      Canadian Spontaneous Coronary Artery Dissection Cohort Study: in-hospital and 30-day outcomes.
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