The Advanced Reperfusion Strategies for Patients With OHCA and Refractory Ventribular Fibrillation (ARREST) trial
enrolled 30 OHCAs (age 18 to 75) with initial shockable rhythms, randomized at hospital
arrival (mean 911-to-randomization interval approximately 50 minutes) to continued
conventional advanced life-support (ACLS) or ECPR (mean 911-to-ECPR interval 59 minutes;
Supplemental Table S1).
1
The ECPR group demonstrated significant improvement in survival to hospital discharge
(43% vs 6.7%) as well as 6-month favourable neurologic outcome (43% vs 0%; Supplemental Table S2). All ECPR-treated patients with poor hospital-discharge neurologic outcomes had
favourable 6-month neurologic outcomes. The Data Safety Monitoring Board (DSMB) terminated
the study early because of clear benefit.To read this article in full you will need to make a payment
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References
- Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial.Lancet. 2020; 396: 1807-1816
- Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment and treatment on functional neurologic outcome in refractory out-of-hospital cardiac arrest.JAMA. 2022; 327: 737
- Surviving refractory out-of-hospital ventricular fibrillation cardiac arrest: critical care and extracorporeal membrane oxygenation management.Resuscitation. 2018; 132: 47-55
- Current use, capacity, and perceived barriers to the use of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest in Canada.CJC Open. 2021; 3: 327-336
- Cost-effectiveness of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a multi-centre prospective cohort study.Resuscitation. 2020; 157: 32-38
Article info
Publication history
Published online: December 13, 2022
Accepted:
December 9,
2022
Received:
August 31,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
See page 4 for disclosure information.
Identification
Copyright
© 2022 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
