Atrial fibrillation (AF), the clinically most common form of arrhythmia, is usually
classified based on its duration: ranging from paroxysmal AF, consisting of self-terminating
episodes lasting typically less than 7 days, to persistent and long-lasting persistent
or chronic AF, in which AF fails to self-terminate.
1
In all the different forms, electrical remodelling occurs. This remodelling further
increases ectopic-triggered activity and provides an electrical substrate even more
prone to re-entry formation—the 2 main arrhythmogenic mechanisms in AF—thereby facilitating
the occurrence and maintenance of AF, as well described in the term “AF begets AF”
by the Allessie group in 1995.
- Lévy S.
- Camm A.J.
- Saksena S.
- et al.
Working Group on Arrhythmias, Working Group on Cardiac Pacing of the European Society
of Cardiology, North American Society of Pacing and Electrophysiology. International
consensus on nomenclature and classification of atrial fibrillation: a collaborative
project of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing
of the European Society of Cardiology and the North American Society of Pacing and
Electrophysiology.
Europace. 2003; 5: 119-122
2
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Canadian Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Working Group on Arrhythmias, Working Group on Cardiac Pacing of the European Society of Cardiology, North American Society of Pacing and Electrophysiology. International consensus on nomenclature and classification of atrial fibrillation: a collaborative project of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.Europace. 2003; 5: 119-122
- Atrial fibrillation begets atrial fibrillation: a study in awake chronically instrumented goats.Circulation. 1995; 92: 1954-1968
- Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression.Circ Res. 2014; 114: 1483-1499
- Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation.Circulation. 2014; 129: 145-156
- Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.Circulation. 2012; 125: 2059-2070
- Late sodium current in human atrial cardiomyocytes from patients in sinus rhythm and atrial fibrillation.PloS One. 2015; 10e0131432
- Ionic mechanisms of electrical remodeling in human atrial fibrillation.Cardiovasc Res. 1999; 44: 121-131
- Differential sodium current remodelling identifies distinct cellular proarrhythmic mechanisms in paroxysmal vs persistent atrial fibrillation.Can J Cardiol. 2023; (xx:xxx-xx)
- Injury current modulates afterdepolarizations in single human ventricular cells.Cardiovasc Res. 2000; 47: 124-132
- Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes.Am J Physiol Heart Circ Physiol. 2007; 293: H2024-H2038
- Mechanisms of sex differences in atrial fibrillation: role of hormones and differences in electrophysiology, structure, function, and remodelling.Europace. 2019; 21: 366-376
- Gender differences in electrophysiological gene expression in failing and non-failing human hearts.PLoS One. 2013; 8e54635
Article info
Publication history
Published online: December 27, 2022
Accepted:
December 25,
2022
Received:
December 21,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
See article by Casini et al., pages xxx-xxx of this issue
See page 2 for disclosure information.
Identification
Copyright
© 2023 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Differential sodium current remodeling identifies distinct cellular pro-arrhythmic mechanisms in paroxysmal versus persistent atrial fibrillationCanadian Journal of Cardiology
- PreviewThe cellular mechanisms underlying progression from paroxysmal to persistent atrial fibrillation (AF) are not fully understood, but alterations in (late) sodium current (INa) have been proposed. Human studies investigating electrophysiological changes at the paroxysmal stage of AF are sparse, with the majority employing right atrial appendage cardiomyocytes (CMs). We here investigated action potential (AP) characteristics and (late) INa remodeling in left atrial appendage CMs (LAA-CMs) from patients with paroxysmal and persistent AF and patients in sinus rhythm (SR), as well as the potential contribution of the “neuronal” sodium channel SCN10A/NaV1.8.
- Full-Text
- Preview
