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Detection of Myocardial Injury After Noncardiac Surgery: Levelling the Troponin Playing Field

Published:January 11, 2023DOI:https://doi.org/10.1016/j.cjca.2023.01.007
Detection of Myocardial Injury After Noncardiac Surgery: Levelling the Troponin Playing Field
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      The troponin complex is made up of regulatory proteins found in cardiac myocytes that are integral to efficient cardiac muscle contraction. The complex is made up of 3 subunits: troponin C (TnC), troponin I (TnI), and troponin T (TnT). During myocardial ischemia, downstream hypoxic effects lead to myocyte cell death and rupture of the cell membrane.
      • Park K.C.
      • Gaze D.C.
      • Collinson P.O.
      • Marber M.S.
      Cardiac troponins: from myocardial infarction to chronic disease.
      Cardiovasc Res. 2017; 113: 1708-1718
      This leads to measurable troponin levels in the circulation.
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      References

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        • Gaze D.C.
        • Collinson P.O.
        • Marber M.S.
        Cardiac troponins: from myocardial infarction to chronic disease.
        Cardiovasc Res. 2017; 113: 1708-1718
        View in Article
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        View in Article
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        View in Article
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        • et al.
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        View in Article
        • Duceppe E.
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        High-sensitivity cardiac troponin i thresholds to identify myocardial injury after noncardiac surgery: a cohort study.
        Can J Cardiol. 2023; 39 (:XXX-XX)
        View in Article

      Article info

      Publication history

      Published online: January 11, 2023
      Accepted: January 10, 2023
      Received: December 22, 2022

      Publication stage

      In Press Journal Pre-Proof

      Footnotes

      See article by Duceppe et al., pages XXX-XX of this issue.

      See page 2 for disclosure information.

      Identification

      DOI: https://doi.org/10.1016/j.cjca.2023.01.007

      Copyright

      © 2023 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

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