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BRIEF SUMMARY
In a prospective cohort of 3953 adults who had in-hospital noncardiac surgery, a postoperative hs-cTnI ≥60 ng/L measured within the first three postoperative days was associated with a >7-fold increase in the risk of subsequent major cardiac events or mortality at 30 days. In patients with hs-cTnI ≥60 ng/L, the incidence of major cardiac events or 30-day mortality was 10.0% compared to 1.0% in patients with hs-cTnI <60 ng/L.
FUNDING
The overall VISION Study was funded by >70 grants and funding sources. Abbott Laboratories provided the hs-cTnI assays and some funding for the analysis. No funding entity had a role in data collection, statistical analysis, manuscript writing, or decision to publish.
DISCLOSURES
ED reports investigator-initiated research grants, lecture fee, and honoraria for advisory board participation from Roche Diagnostics, and investigator-initiated research grants from Abbott Diagnostics. FKB reports investigator-initiated research grant from Siemens Healthcare Diagnostics and Roche Diagnostics. PK has received grants, reagents, consultant, advisor, honoraria from Abbott Laboratories, Abbott Point of Care, Beckman Coulter, Ortho Clinical Diagnostics, Randox Laboratories, Roche Diagnostics, Quidel, Siemens Healthcare Diagnostics and Thermo Fisher Scientific. McMaster University has filed patents with Dr. Kavsak listed as an inventor in the acute cardiovascular biomarker field. RP RP has received research grants and/or honoraria from Edwards Lifesciences, Intersurgical and GloaxoSmithkline. CM reports research grants from Swiss National Science Foundation, grants from Swiss Heart Foundation, support from University Hospital Basel, the University of Basel, Novartis, Abbott, Beckman, Roche Diagnostics, Novartis, Singulex, BRAHMS, Quidel, Mitsubishi, Ortho Clinical, Siemens, Astra Zeneca, and Boehringer Ingelheim, all outside the submitted work. PJD is a member of a research group with a policy of not accepting honorariums or other payments from industry for their own personal financial gain. They do accept honorariums/payments from industry to support research endeavours and costs to participate in meetings. Based on study questions PJD has originated and grants he has written, he has received grants from Abbott Diagnostics, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers-Squibb, CloudDX, Coviden, Octapharma, Philips Healthcare, Roche Diagnostics, Siemens and Stryker. PJD has participated in advisory board meetings for GlaxoSmithKline, Boehringer Ingelheim, Bayer and Quidel Canada. He attended an expert panel meeting with AstraZeneca and Boehringer Ingelheim and he was Consultant for a call with Roche Pharma and consultant work with Trimedic. He has also been invited as a speaker with Bayer Inc and Novartis Pharma Canada. All other authors have no conflict to disclose.
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- Detection of Myocardial Injury After Noncardiac Surgery: Levelling the Troponin Playing FieldCanadian Journal of Cardiology
- PreviewThe troponin complex is made up of regulatory proteins found in cardiac myocytes that are integral to efficient cardiac muscle contraction. The complex is made up of 3 subunits: troponin C (TnC), troponin I (TnI), and troponin T (TnT). During myocardial ischemia, downstream hypoxic effects lead to myocyte cell death and rupture of the cell membrane.1 This leads to measurable troponin levels in the circulation.
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