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Canadian Journal of Cardiology

The impact of COVID-19 on the social determinants of cardiovascular health

  • Mark A Faghy
    Correspondence
    Corresponding Author: Dr Mark Faghy, Biomedical Research Theme, School of Human Sciences, University of Derby, Derby, UK.
    Affiliations
    Biomedical Research Theme, School of Human Sciences, University of Derby, Derby, UK

    Department of Physical Therapy, College of Applied Sciences, the University of Illinois at Chicago, Chicago, IL

    Healthy Living for Pandemic Event Protection (HL – PIVOT) Network, Chicago, IL
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  • Ruth EM Ashton
    Affiliations
    Biomedical Research Theme, School of Human Sciences, University of Derby, Derby, UK

    Healthy Living for Pandemic Event Protection (HL – PIVOT) Network, Chicago, IL
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  • Lewis Gough
    Affiliations
    Human Performance and Health Group, Centre for Life and Sport Sciences (CLaSS), School of Health Sciences, Birmingham City University, Birmingham, UK
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  • Ross Arena
    Affiliations
    Biomedical Research Theme, School of Human Sciences, University of Derby, Derby, UK

    Department of Physical Therapy, College of Applied Sciences, the University of Illinois at Chicago, Chicago, IL

    Healthy Living for Pandemic Event Protection (HL – PIVOT) Network, Chicago, IL
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  • Carl J Lavie
    Affiliations
    Healthy Living for Pandemic Event Protection (HL – PIVOT) Network, Chicago, IL

    Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, New Orleans, LA, USA
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  • Cemal Ozemek
    Affiliations
    Department of Physical Therapy, College of Applied Sciences, the University of Illinois at Chicago, Chicago, IL

    Healthy Living for Pandemic Event Protection (HL – PIVOT) Network, Chicago, IL
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Published:March 10, 2023DOI:https://doi.org/10.1016/j.cjca.2023.02.073

      Abstract:

      Cardiovascular disease (CVD) is the leading non-communicable disease and cause of premature mortality globally. Despite well-established evidence of a cause-effect relationship between modifiable lifestyle behaviours and the onset of risk of chronic disease, preventative approaches to curtail increasing prevalence have been ineffective. This has undoubtedly been exacerbated by the coronavirus disease 2019 (COVID-19) pandemic, which saw widespread national lockdowns implemented to reduce transmission and alleviate pressure on strained healthcare systems. An unintended consequence of these approaches was a well-documented negative impact on population health in the context of both physical and mental well-being. Whilst the true extent of the impact of the COVID-19 pandemic on global health has yet to be fully realised or understood, it seems prudent to review effective preventative and management strategies that have yielded positive outcomes across the spectrum (i.e., individual to society). There is also a clear need to heed lessons learnt from the COVID-19 pandemic in the power of collaboration and how this can be used in the design, development, and implementation of future approaches to address the longstanding burden of CVD.

      Keywords

      Introduction

      Cardiovascular (CV) disease (CVD) is a prominent non-communicable disease (NCD) phenotype that may be characterized as a group of interacting disorders that includes coronary heart disease, cerebrovascular disease, and stroke. Collectively, CVD is the leading cause of morbidity and premature mortality on a global scale,

      World Health Organisation. Non communicable diseases. Noncommunicable diseases. Published March 8, 2022. Accessed March 8, 2022. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases

      , currently responsible for 18 million deaths and 366 million disability-adjusted life years lost each year

      Vervoort D, Pezzella AT. Global Cardiac Surgery and the Global Burden of Disease. In: Global Cardiac Surgery Capacity Development in Low and Middle Income Countries. Springer; 2022:101-106.

      . Decades of research have established a cause-effect relationship that exists between modifiable lifestyle behaviours and the onset of risk of premature chronic disease
      • Arena R
      • Lavie CJ
      The global path forward – Healthy Living for Pandemic Event Protection (HL – PIVOT).
      ,
      • Arena R
      • Lavie CJ
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      • Network HP
      What Comes First, the Behavior or the Condition? In the COVID-19 Era, It May Go Both Ways.
      . Modifiable lifestyle behaviours are behaviours that can be changed and have a profound impact on physical and mental health
      • Arena R
      • Guazzi M
      • Lianov L
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      Healthy lifestyle interventions to combat noncommunicable disease-a novel nonhierarchical connectivity model for key stakeholders: a policy statement from the American Heart Association, European Society of Cardiology, European Association for Cardiovascular Prevention and Rehabilitation, and American College of Preventive Medicine.
      . Physical inactivity and a poor diet are two of the most pertinent unhealthy lifestyle risk factors for CVD
      • Faghy MA
      • Yates J
      • Hills AP
      • et al.
      Cardiovascular disease prevention and management in the COVID-19 era and beyond: An international perspective.
      , which are both preventable and reversible

      Younus A, Aneni EC, Spatz ES, et al. A systematic review of the prevalence and outcomes of ideal cardiovascular health in US and non-US populations. In: Mayo Clinic Proceedings. Vol 91. Elsevier; 2016:649-670.

      . Arguably, the most effective public health strategy is primary prevention where modifying lifestyle choices can reduce the risk of developing CVD by up to 80%8 9. Despite a plethora of evidence to support the relationship between lifestyle behaviours and chronic disease, previous and universal approaches to counter increasing prevalence and the subsequent impact on healthcare providers are confounded by the complex and interactive nature of chronic disease
      • Pronk NP
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      . Previous attempts by international governments and health agencies to influence healthy lifestyle choices have been confounded by poor adherence, accessibility, and scalability
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      . In addition, the broad nature of interacting factors is often neglected and considered in the design, development and implementation of prevention and optimal management efforts to achieve population-level effectiveness. To add further complexity, the coronavirus disease 2019 (COVID-19) pandemic precipitated an unprecedented global healthcare challenge
      • Graham MM
      • Simpson CS
      The Indirect Impact of COVID-19 on Cardiac Care and Outcomes: Lessons From a Stretched System.
      . During this time, unhealthy lifestyle behaviours were exacerbated and have been once again thrust into the forefront of public attention. Unhealthy lifestyle behaviours (e.g., poor quality diet, lack of physical inactivity, and tobacco/alcohol use) are major contributors to the global burden of disease

      GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Lond Engl. 2018;392(10159):1923-1994. doi:10.1016/S0140-6736(18)32225-6

      .
      Whilst the longstanding impact of the COVID-19 pandemic on lifestyle behaviours and chronic disease is yet to be realised, it has almost certainly contributed to a worsening in trends of population-level cardiometabolic risk factors
      • Lau D
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      Implications of the COVID-19 pandemic for cardiovascular disease and risk-factor management.
      ,
      • Ashton RE
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      The acute and chronic implications of the COVID-19 virus on the cardiovascular system in adults: A systematic review.
      . Although empirical methodologies lack consistency, reports clearly demonstrate important changes in lifestyle behaviours and well-being due to imposed social distancing measures and other preventative restrictions to curtail transmission

      Tronco Hernández YA, Fabio P, Faghy M, Roscoe CM, Maratos FA. Influence of the COVID-19 lockdown on the physical and psychosocial well-being and work productivity of remote workers: cross-sectional correlational study. Published online 2021.

      . Of significant interest is the impact of a persisting symptom profile beyond an acute infection, now referred to as post-COVID syndrome or Long COVID. This presents a rapidly evolving global health crisis

      Faghy MA, Owen R, Thomas C, et al. Is Long COVID the next global health crisis? J Glob Health. Published online In Press.

      that significantly limits functional capacity and exists with a broad array of clinical presentations that is inclusive of CVD complications
      • Faghy MA
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      • Arena R
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      COVID-19 patients require multi-disciplinary rehabilitation approaches to address persisting symptom profiles and restore pre-COVID quality of life.
      . As the world begins its recovery following the COVID-19 pandemic, there is a significant opportunity to improve public health and well-being that should not be squandered; this opportunity is inclusive of combating the long-standing NCD crisis. Accordingly in this review, we provide a summary of effective prevention and management strategies that can be implemented to address the growing burden that is and will continue to impact global health and well-being.

      The Role of Health and Fitness as a Primary Marker of CV Health

      Cardiorespiratory fitness (CRF) is a primary marker of health, resiliency and longevity
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      ,
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      Inverse Relationship of Maximal Exercise Capacity to Hospitalization Secondary to Coronavirus Disease 2019.
      . It is established that individuals that are genetically predisposed to developing chronic diseases but maintain a healthy lifestyle and have a preserved CRF across the lifespan have a lower level of risk for developing CVD
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      Genetic risk, adherence to a healthy lifestyle, and coronary disease.
      ,
      • Ozemek C
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      An update on the role of cardiorespiratory fitness, structured exercise and lifestyle physical activity in preventing cardiovascular disease and health risk.
      . Figure 1 highlights the roles and importance of CRF and other key behavioural characteristics that can be targeted in those individuals that lead unhealthy lifestyles and are subsequently diagnosed with a chronic disease, but then make dramatic changes that emulate a healthy lifestyle can reverse and limit the longstanding implications associated with chronic disease
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      Reduced physical activity in young and older adults: metabolic and musculoskeletal implications.
      . In a community-based cohort study of 387,109 UK adults, Hamer et al. demonstrated that those individuals with positive lifestyle behaviours (defined as those that promote improved health outcomes) and characteristics had a lower incidence of hospitalization due to COVID-19 infection after adjustment for chronic conditions (i.e., CVD and hypertension), supporting the assertion that healthy lifestyle behaviours provide a protective mechanism despite a previous chronic disease diagnosis
      • Hamer M
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      • Gale CR
      • Batty GD
      Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK.
      . In addition, Sallis et al. reported an increased risk of adverse outcomes when infected with COVID-19 in those who were physically inactive
      • Sallis R
      • Young DR
      • Tartof SY
      • et al.
      Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients.
      . Whilst data during the acute stages highlight the protective benefits of healthy lifestyle behaviours, more surveillance research into the effects this has on the development of Long COVID, and chronic disease is needed. Whilst more research is needed to scale up this finding and to stratify it relative to co-morbidities and other healthy living behaviours, initial findings indicate a further complexity in the global response to chronic disease.
      Figure thumbnail gr1
      Figure 1Modifiable lifestyle behaviours that impact the prevalence of cardiovascular disease which has been impacted by COVID-19.
      Effective Strategies to Maintain and Improve CV Health
      The primary prevention strategy for improving CV health is through modifying lifestyle behaviours; higher CV health is also associated with being less susceptible to a COVID-19 infection and a reduction in severe outcomes and symptomology

      Arena R, Bond S, Calvo IR, et al. Shelter from the cytokine storm: Healthy living is a vital preventative strategy in the COVID-19 era. Prog Cardiovasc Dis. Published online 2021.

      ,
      • Arena R
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      Cardiopulmonary exercise testing as a vital sign in patients recovering from COVID-19.
      . These lifestyle behaviours primarily consist of following good nutritional behaviours and being physically active, as these two modifiable factors can nourish the immune system and reduce the inflammatory response following infection
      • Harrison SL
      • Buckley BJ
      • Rivera-Caravaca JM
      • Zhang J
      • Lip GY
      Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews.
      ,
      • Calder PC
      Nutrition and immunity: lessons for COVID-19.
      . This is important due to an elevated inflammatory response that comes to light during COVID-19, characterized as a ‘cytokine storm’ (i.e., a cascade of cytokine (and chemokine) production which results in leukocyte infiltration and activation that can cause tissue damage and organ dysfunction)
      • Fajgenbaum DC
      • June CH
      Cytokine Storm.
      . Reducing the incidence of this phenomenon is therefore vital to protect CV health and reduce the chances of severe outcomes for patients with COVID-19.
      Adequate and balanced nutrition is imperative to optimise immune system function and our body’s response to infections
      • Calder PC
      Nutrition and immunity: lessons for COVID-19.
      . Observational studies demonstrate that individuals with a ‘normal’ body mass are less likely to experience COVID-19 hospitalisations and reduced symptomology

      Sharma A, Garg A, Rout A, Lavie CJ. Association of obesity with more critical illness in COVID-19. In: Mayo Clinic Proceedings. Vol 95. Elsevier; 2020:2040-2042.

      . Equally, Harrison et al. recently observed obesity to have an association with mortality from COVID-19 (Odds ratio (OR): 2.18, 95% CI: 1.10-4.34)
      • Harrison SL
      • Buckley BJ
      • Rivera-Caravaca JM
      • Zhang J
      • Lip GY
      Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews.
      . This could be linked to low chronic low-grade inflammation and higher anti-inflammatory cytokines from poor nutrition. Contrastingly, a healthy diet may offer protective effects for CV health and thus, the severity of COVID-19. Moreover, the nutritional status of individuals has also been associated with vaccination effectiveness, whereby low intake of micronutrients (particularly malnourishment) seemed to impair the protection gained from vaccines
      • Rayman MP
      • Calder PC
      Optimising COVID-19 vaccine efficacy by ensuring nutritional adequacy.
      . Given that both a lack of nutrients and being obese will negatively impact CV health leading potentially to metabolic syndrome, it is clear from this evidence that nutrition is a modifiable factor that could help sustain CV health and reduce the severe consequences of COVID-19. This is an area of great concern given the sharp increase in the rates of obesity, particularly in the western world
      • Arena R
      • Lavie CJ
      The global path forward – Healthy Living for Pandemic Event Protection (HL – PIVOT).
      , which may yet be magnified by reduced access to recreational facilities and an increase in sedentary behaviour (SB) throughout the pandemic. The lasting impacts the COVID-19 pandemic will have on lifestyle behaviours and the influence of CV risk factors have yet to be established; initial trends are not certainly troubling for the future. As such, the promotion of healthy lifestyle behaviours is a critical area of consideration for the development of strategies to improve CV outcomes, from both the primary and secondary prevention perspective.
      A healthy diet can work synergistically with appropriate levels of PA to improve CV health and reduce negative COVID-19 outcomes. Participating in exercise improves mitochondrial function by initially increasing the acute levels of reactive oxygen species that upregulates mitochondrial biogenesis, as well as super oxygen dismutase, catalase, and glutathione peroxidase
      • Mankowski RT
      • Anton SD
      • Buford TW
      • Leeuwenburgh C
      Dietary antioxidants as modifiers of physiologic adaptations to exercise.
      . These effects reinforce our antioxidant defence systems and improve immunity, which is critical to a cell’s ability to respond to viral infections such as COVID-19 34. Accordingly, Tavakol et al. demonstrated that those demonstrating low PA levels (p=0.05) or low metabolic equivalent (MET).min/week (p=0.03) were more likely to experience increased disease severity
      • Tavakol Z
      • Ghannadi S
      • Tabesh MR
      • et al.
      Relationship between physical activity, healthy lifestyle and COVID-19 disease severity; a cross-sectional study.
      . It is well established that avoiding SB or conversely engaging in regular PA is a key factor of CV health
      • Lavie CJ
      • Ozemek C
      • Carbone S
      • Katzmarzyk PT
      • Blair SN
      Sedentary behavior, exercise, and cardiovascular health.
      , outlined in more detail below. It is important to note that the intensity of exercise is a modifiable factor and moderate exercise is preferable to intense exercise, whereby the latter can lead to immunosuppression of anti-inflammatory cytokines and thus, greater susceptibility to infection
      • Da Silveira MP
      • da Silva Fagundes KK
      • Bizuti MR
      • Starck É
      • Rossi RC
      • de Resende E Silva DT
      Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature.
      . Further strategies to improve CV health and COVID-19 complications are to avoid behaviours, such as those that can damage the liver (e.g., alcohol) or the respiratory system (e.g., smoking), as these have also been associated with a higher risk of mortality (liver disease OR: 2.81, 95% CI: 1.31-6.01, smoking OR: 1.46, 95% CI: 0.83-2.60) and severity of symptoms (liver disease OR: 0.81, 95% CI: 0.47,1.4, smoking OR: 1.80, 95% CI: 1.14-2.85)
      • Harrison SL
      • Buckley BJ
      • Rivera-Caravaca JM
      • Zhang J
      • Lip GY
      Cardiovascular risk factors, cardiovascular disease, and COVID-19: an umbrella review of systematic reviews.
      . Several modifiable factors can function as preventative tools to help individuals protect their CV health and susceptibility to a severe or life-threatening response to a COVID-19 infection. Equally, behavioural changes could reduce the impact of the cytokine storm that is apparent with a COVID-19 infection through improved immunity. Adhering to healthy lifestyle behaviours which include healthy nutrition and PA is critical in the response moving forward to weaken the grip the virus has on the global population.
      Strategies to Manage or Mitigate the Implications of Reduced CV Health
      Prior to the COVID-19 pandemic, the protective effects of PA in the management of chronic conditions were well established

      Harber MP, Peterman JE, Imboden M, et al. Cardiorespiratory fitness as a vital sign of CVD risk in the COVID-19 era. Prog Cardiovasc Dis. Published online 2022.

      . Whilst the mechanisms of action are multifactorial, they include improved or normalized vascular function, blood pressure, weight loss, glycemic regulation, lipid profile, mitochondrial function, stress reduction and quality of life

      Committee P. 2018 Physical Activity Guidelines Advisory Committee Scientific Report. Published online 2018:779.

      . The association between PA and CV health has determined a minimum volume of activity to produce a clinically meaningful reduction in the risk of CV events alongside strategies to maximise health benefits. The benefits of accumulating 150-300 minutes of moderate-intensity PA and performing two days of muscle-strengthening activities and the benefits for sleep quality are associated with reduced anxiety, improving cognition and improving insulin sensitivity

      Committee P. 2018 Physical Activity Guidelines Advisory Committee Scientific Report. Published online 2018:779.

      . Previous recommendations highlight that bouts of at least 10 minutes of aerobic PA were needed to count towards the weekly allotment of PA, however, bouts <10 minutes also provide positive health benefits and reduce mortality risk
      • White DK
      • Gabriel KP
      • Kim Y
      • Lewis CE
      • Sternfeld B
      Do short spurts of physical activity benefit cardiovascular health? The CARDIA Study.
      . This is meaningful when promoting PA to individuals living sedentary and/or physically inactive lives that may perceive planning for structured activities lasting 10 or more minutes as untenable. Alternatively, high-volume, high-intensity exercise emerged as a key strategy for improving CRF in all participants completing 1,800 and 3,000 kcal/week for men and women respectively. High-intensity interval training along with time-efficient forms of training has gained traction. Interventions such as vigorously climbing three flights of stairs, three times per day, separated by a four-hour recovery period, three days/week for at least six weeks contributed to improved CRF and presented potential real-world application in the workplace
      • Jenkins EM
      • Nairn LN
      • Skelly LE
      • Little JP
      • Gibala MJ
      Do stair climbing exercise “snacks” improve cardiorespiratory fitness?.
      , where sedentary behaviours are prominent
      • Faghy MA
      • Duncan MJ
      • Pringle A
      • Meharry JB
      • Roscoe CMP
      UK university staff experience high levels of sedentary behaviour during work and leisure time.
      . Even more efficient was performing five, four-second all-out sprints with 45-second rest periods every hour over eight hours on a cycle ergometer that decreased postprandial plasma triglyceride metabolism and increased whole-body fat oxidation
      • Wolfe AS
      • Burton HM
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      • Coyle EF
      Hourly 4-s sprints prevent impairment of postprandial fat metabolism from inactivity.
      .
      Despite recognition of the health-related benefits of physically activity, only a quarter of adults reported meeting the aerobic and strengthening components of the PA guidelines prior to the COVID-19 pandemic

      Committee P. 2018 Physical Activity Guidelines Advisory Committee Scientific Report. Published online 2018:779.

      . It is clear that national lockdowns contributed to further reductions in PA,

      Lefferts EC, Saavedra JM, Song BK, Lee D chul. Effect of the COVID-19 pandemic on physical activity and sedentary behavior in older adults. J Clin Med. 2022;11(6):1568.

      increases in SB and all-round disturbance to positive health behaviours
      • Oliveira MR
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      • et al.
      Covid-19 and the impact on the physical activity level of elderly people: A systematic review.
      ,
      • Swain P
      • James E
      • Laws JM
      • et al.
      COVID-19: self-reported reductions in physical activity and increases in sedentary behaviour during the first national lockdown in the United Kingdom.
      . Reduced recreational activities, active travel time and daily activities were significantly associated with lower PA levels. While PA levels were reduced across all age groups, the already low levels of PA in older adults before the pandemic were exacerbated during the lockdown. Browne and colleagues reported PA and SB data in a group of hypertensive older adults before and during the pandemic
      • Browne RA
      • Macêdo GA
      • Cabral LL
      • et al.
      Initial impact of the COVID-19 pandemic on physical activity and sedentary behavior in hypertensive older adults: An accelerometer-based analysis.
      . On average, participants took 5,809 steps/day, accumulated 303 minutes/day of light PA, 15.5 minutes/day of moderate-vigorous PA and 653 minutes of sedentary time. When measured during the pandemic, there was a decrease of nine hundred steps/per day, 2.8 minutes/per day of moderate to vigorous PA, 26.6 minutes of light activity and a 30-minute increase in sedentary time
      • Browne RA
      • Macêdo GA
      • Cabral LL
      • et al.
      Initial impact of the COVID-19 pandemic on physical activity and sedentary behavior in hypertensive older adults: An accelerometer-based analysis.
      . This data is sobering when considering that SBs significantly increases the risk of developing CVD. In a previous investigation, sedentary time in healthy older adults was associated with a 22% and 27% better likelihood of having a cluster of traditional CVD risk factors in women and men, respectively

      Sandbakk SB, Nauman J, Zisko N, et al. Sedentary time, cardiorespiratory fitness, and cardiovascular risk factor clustering in older adults–the Generation 100 study. In: Mayo Clinic Proceedings. Vol 91. Elsevier; 2016:1525-1534.

      . It is important to recognise that those with an established management plan during the pandemic, likely lost contact with physicians due to a reprioritisation of clinical staff to address the challenges of COVID-19 49. Contact with care providers is an effective strategy to maintain engagement with lifestyle interventions but a reduction in contact/access during the pandemic may have led to attrition and a worsening of patient outcomes
      • Ganatra S
      • Dani SS
      • Shah S
      • et al.
      Management of cardiovascular disease during coronavirus disease (COVID-19) pandemic.
      . Whilst challenging and representing a big step change, one positive response was to move the delivery of effective cardiac rehabilitation (CR) services to a virtual platform
      • Babu AS
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      COVID-19: A Time for Alternate Models in Cardiac Rehabilitation to Take Centre Stage.
      . Assisted with bespoke guidance and recommendations
      • Moulson N
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      SARS-CoV-2 cardiac involvement in young competitive athletes.
      , the role of virtual care made use of available technologies and platforms to increase accessibility
      • de Araújo CGS
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      A Multiprofessional Face-to-Face and Remote Real-Time Hybrid Mode of Exercise-Based Cardiac Rehabilitation: An Innovative Proposal During the COVID-19 Pandemic.
      . This resulted in the development and implementation of safe, translational, effective, and adaptable CR services for patients
      • Van Iterson EH
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      . Early data demonstrates that remote, synchronous [(live virtual CR monitoring or hybrid (virtual CR and in-person CR sessions)] models of CR delivery are potential ways to improve access and increase capacity for underserved patients who could benefit from CR participation
      • Ganeshan S
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      Clinical Outcomes and Qualitative Perceptions of In-person, Hybrid, and Virtual Cardiac Rehabilitation.
      ,

      Nkonde-Price C, Reynolds K, Najem M, et al. Comparison of Home-Based vs Center-Based Cardiac Rehabilitation in Hospitalization, Medication Adherence, and Risk Factor Control Among Patients With Cardiovascular Disease. JAMA Netw Open. 2022;5(8):e2228720-e2228720.

      .
      The impact of lockdowns on PA is not disputed, favourable trends began to emerge once it became clear that a quick resolution to the pandemic was not plausible. With enrollment and membership to health/fitness centres reduced due to limited capacity and/or member hesitancy, individuals turned to spending more time being physically active outside, finding creative ways of increasing PA indoors and/or investing in home fitness equipment. The development of fitness phone applications outpaced previous years’ rates
      • Kalgotra P
      • Raja U
      • Sharda R
      Growth in the development of health and fitness mobile apps amid COVID-19 pandemic.
      along with increases in self-powered or electronic bicycle sales
      • Francke A
      Cycling during and after the COVID-19 pandemic.
      . Though there are many contributing reasons, it is likely that those that were able to work remotely effectively eliminated or decreased weekly automotive commutes to and from work.

      A Global Call to Action

      Notwithstanding the well-documented benefits of healthy living behaviours, availability of knowledge and advancements in medicine, technology, and an array of global initiatives over several decades, there has been little change in public health outcomes. Despite a plethora of initiative-taking models’ and global strategies to promote healthy living behaviours, these approaches have been ineffective as CVD prevalence data does not show any signs of improvement and will burden healthcare settings for decades to come

      Jayasinghe S, Faghy MA, Hills AP. Social justice equity in healthy living medicine - An international perspective. Prog Cardiovasc Dis. Published online April 28, 2022. doi:10.1016/j.pcad.2022.04.008

      . Whilst proactive and preventive approaches are most impactful
      • Arena R
      • Faghy M
      • Laddu D
      A perpetual state of bad dreams: The prevention and management of cardiovascular disease in the COVID-19 pandemic era and beyond.
      , these approaches have been hindered by a lack of integration, differentiation, acceptability, and scalability above a local or national level. Given the urgency, it is appropriate to establish global health policies that are enriched with behavioural, implementation and system science approaches to coordinate a holistic approach to addressing the current and future global health threats

      Pronk NP, Mabry PL, Bond S, Arena R, Faghy MA. Systems science approaches to cardiovascular disease prevention and management in the era of COVID-19: A Humpty-Dumpty dilemma? Prog Cardiovasc Dis. Published online December 20, 2022. doi:10.1016/j.pcad.2022.12.003

      . Whilst the health threats of the ever-evolving circumstances are an immediate concern to global health and well-being, the ongoing and widespread prevalence of CV health issues seen globally is a pre-existing pandemic by its very own nature. Exercise and PA that is effective and accessible via consistent and equitable approaches across nations will seek to address CV health issues. Therefore, international policymakers and decision-makers should prioritise and instil an ‘exercise/healthy living is medicine’ message across the lifespan and including education on PA and literacy to embed habitual exercise into the global population
      • Gill TP
      • Boylan S
      Public health messages: why are they ineffective and what can be done?.
      ,
      • Whitsel LP
      • Ajenikoko F
      • Chase PJ
      • et al.
      Public policy for healthy living: How COVID-19 has changed the landscape.
      .
      Initiatives by leading organisations such as the World Health Organisation and the National Institute of Health to address public health challenges have raised awareness of CVD and the associated risk factors. However, their attempts to address global health suffer from a lack of compelling evidence of the effectiveness in thwarting the trajectory and prevalence of CVD and chronic disease more broadly. Indeed, recent reports from the United Kingdom House of Commons Report on Grassroots participation in sports and physical activity identified that despite a mission statement and promised legacy to increase the number of adults participating in recreational and competitive sports and an £8.8 billion investment, the 2012 Olympic Games in London failed to influence participation levels entirely

      Department for Digital, Culture, Media & Sport. Grassroots participation in sport and physical activity - National Audit Office (NAO) report. National Audit Office (NAO). Accessed January 10, 2023. https://www.nao.org.uk/reports/grassroots-participation-in-sport-and-physical-activity/

      . It is conceivable that all interested parties share the ambition to improve population health but there is a lack of global representation and widespread opportunity to engage with such agencies to inform decision-making, implementation, and reporting processes. What is most evident is a lack of consideration and global thinking from established health agencies to adopt and implement unified health agendas that could be effective in improving global public health.
      In the wake of COVID-19, unhealthy lifestyle behaviours and chronic disease have been amongst society throughout history but what was a pre-existing and sizeable challenge to public health has undoubtedly been accelerated and even synergized
      • Faghy M
      • Arena R
      • Hills AP
      • et al.
      The response to the COVID-19 pandemic: With hindsight what lessons can we learn?.
      . The key to successfully addressing the chronic disease burden can be firstly achieved via formal recognition from international governments and non-government agencies. Global attempts can then be implemented within health authorities, international governments and academic researchers working collaboratively with deep interdisciplinary practice. Under the remit of healthy living medicine, holistic approaches to improving access and widespread adoption of healthy living behaviours should be devised in a manner that will benefit the population’s health and well-being for years to come.

      Conclusion

      With rising prevalence and the impact upon healthcare settings, there is a need to develop cohesive interventions that are accessible and can be implemented at scale to instil healthy living behaviours at a global level. This might appear idealistic but there is a need for a global health infrastructure that is supported with appropriate investment. This could also include data modernization and improved surveillance mechanisms that are transient and reflected by mass media coverage is needed to make this panacea a reality. COVID-19 has served those with an interest in public health a stark reminder that adopting reactive approaches to public health challenges may not be in the public’s best interests. We must therefore work collaboratively to establish effective, scalable, and sustainable approaches and increase the recognition and implementation of precision public health.

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